Document Detail

Effects of increased intracranial pressure on pulmonary vascular resistance of fetal and neonatal goats.
MedLine Citation:
PMID:  18019     Owner:  NLM     Status:  MEDLINE    
The effects of increased intracranial pressure on the pulmonary circulation were investigated in fetal and neonatal goats. Pulmonary vascular resistance and systemic arterial pressure increased with elevation of intracranial pressure in neonatal animals. Alpha-adrenergic blockade completely eliminated both of these responses. The response of the fetal pulmonary circulation was unlike that seen in the postnatal animal. Although there was a slight elevation of pulmonary vascular resistance initially, the predominant response was a decrease in resistance. The decrease in fetal pulmonary vascular resistance was unaffected by phenoxybenzamine, but reversed by propranolol. After the beta-adrenergic blockade, increased intracranial pressure produced an increase in pulmonary vascular resistance. Similarly, ventilation of fetal lungs resulted in an increase in pulmonary vascular resistance after increased intracranial pressure. These results demonstrate for the first time that pulmonary vascular resistance may be altered in fetal and neonatal animals by increasing intracranial pressure. The elevation of pulmonary vascular resistance after elevated intracranial pressure must be due to an active pulmonary vascular constriction.
J R Hessler; S Cassin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  232     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-08-25     Completed Date:  1977-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H671-5     Citation Subset:  IM    
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MeSH Terms
Age Factors
Animals, Newborn / blood,  physiology*
Carbon Dioxide / blood
Fetal Blood / analysis
Fetus / physiology*
Gestational Age
Hydrogen-Ion Concentration
Intracranial Pressure*
Oxygen / blood
Phenoxybenzamine / pharmacology
Propranolol / pharmacology
Pulmonary Circulation*
Regional Blood Flow
Vascular Resistance* / drug effects
Reg. No./Substance:
124-38-9/Carbon Dioxide; 525-66-6/Propranolol; 59-96-1/Phenoxybenzamine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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