| Effects of increased intracranial pressure in brain surface microcirculation in rats. | |
| | |
MedLine Citation:
|
PMID: 7847139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of increased intracranial pressure (ICP) on pial vessel diameters were investigated in rats using a cranial window and fluorescence microscopy. The brain surface was superfused with mock cerebro-spinal fluid (CSF) at a constant rate (5 ml/h), and the ICP was raised up to 20 mmHg by elevating a CSF-reservoir connected to the CSF-outlet of the window. Arterioles dilated as the ICP increased (+ 12% dilation at 20 mmHg ICP). Following a rapid reduction of the raised ICP to normal, arteriolar diameters did not return to control values (+ 7% dilatation), while venules dilated (+ 3%), indicating reactive hyperaemia. At this time, CO2 inhalation induced a low response in the arterioles (+ 0.4%/mmHg PaCO2 increase) and an over-response in the venules (+ 0.3%/mmHg). The CO2 response decreased in smaller arterioles (< or = 30-40 microns phi). In addition, a few animals showed extravasation of Na(+)-fluorescein administered intravenously. Our results indicate that reactive hyperaemia can take place following a rapid return from an increased ICP to an normal level, even in cases of mild intracranial hypertension; a disruption of the blood-brain barrier may follow. |
| | |
Authors:
|
S Kawamura; N Yasui |
Related Documents
:
|
21096989 - Non-invasive intracranial pressure estimation using support vector machine. 11773819 - Treatment of transtentorial herniation unresponsive to hyperventilation using hypertoni... 18004969 - Optic nerve sheath fenestration for vision preservation in idiopathic intracranial hype... 11907399 - Metoclopramide-induced raised intracranial pressure after head injury. 3111189 - Self-retaining brain retractor pressure during intracranial procedures. 19948619 - Continuous monitoring of cerebrovascular pressure reactivity after traumatic brain inju... 23147329 - Hemodynamic changes comparing lidocaine hcl with epinephrine and articaine hcl with epi... 23257249 - High-frequency jet ventilation during video-assisted thoracoscopic surgery in apatient ... 3893139 - Inhibition of the epinephrine-induced reduction of intraocular pressure by systemic ind... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta neurochirurgica Volume: 128 ISSN: 0001-6268 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 1994 |
Date Detail:
|
Created Date: 1995-03-09 Completed Date: 1995-03-09 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: AUSTRIA |
Other Details:
|
Languages: eng Pagination: 21-5 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, Research Institute for Brain and Blood Vessels-Akita, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arterioles / physiology Blood-Brain Barrier Brain / blood supply* Intracranial Pressure* Male Microcirculation / physiology* Microscopy, Fluorescence Rats Rats, Sprague-Dawley Vasoconstriction |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anomaly of venous system in congenital occipital dermal sinus.
Next Document: Development of the neurocranium after transsutural fixing by new, resorbable poly-L-lactide miniplat...