| Effects of increased inspired oxygen concentration on tissue oxygenation: theoretical considerations. | |
| | |
MedLine Citation:
|
PMID: 19809323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND OBJECTIVES: Breathing increased fractional oxygen concentration (FiO2) is recommended for the treatment of tissue ischaemia. METHODS: The theoretical benefits of increasing FiO2 on tissue oxygenation were evaluated using standard physiological equations. Assuming constant oxygen consumption by tissues throughout the length of a capillary, the oxygen content at 20 arbitrary points along a capillary was calculated. Using mathematical representations of the haemoglobin dissociation curve and an iterative approach to include the dissolved oxygen component of oxygen content, the oxygen partial pressure (PO2) profile along a capillary was estimated. RESULTS: High FiO2 concentrations cause large increases in PO2 at the arteriolar end of capillaries but these large PO2 values, caused by the extra dissolved oxygen, rapidly decline along the capillary. At the venular end of the capillary (the area of tissue most likely to be hypoxic), breathing oxygen causes only a modest improvement in PO2. CONCLUSION: Increasing FiO2 to treat tissue hypoxia has clear benefits, but a multimodal approach to management is required. |
| | |
Authors:
|
Andrew B Lumb; Sindhu Nair |
Related Documents
:
|
7696063 - Breath-by-breath analysis of oxygen uptake using the datex ultima. 18091553 - Effects of ventilation with 100% oxygen during early hyperdynamic porcine fecal periton... 430133 - Alteration of posttraumatic ischemia in experimental spinal cord trauma by a central ne... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: European journal of anaesthesiology Volume: 27 ISSN: 1365-2346 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-09 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: England |
Other Details:
|
Languages: eng Pagination: 275-9 Citation Subset: IM |
Affiliation:
|
Anaesthetic Department, St James's University Hospital, Leeds, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Capillaries / physiology Computer Simulation* Humans Inhalation / physiology* Models, Biological* Oxygen / administration & dosage, metabolism* Oxygen Consumption / physiology* Oxygen Inhalation Therapy* / methods Partial Pressure |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: What is neuroethics? Empirical and theoretical neuroethics.
Next Document: Effects of articaine and ropivacaine on calcium handling and contractility in canine ventricular myo...