Document Detail

Effects of increased calcium, phosphorus, and vitamin D intake on bone mineralization in very low-birth-weight infants fed formulas with Polycose and medium-chain triglycerides.
MedLine Citation:
PMID:  7086598     Owner:  NLM     Status:  MEDLINE    
The ideal postnatal rate of bone mineralization in preterm infants is unknown. In this study the effect of a new formula on bone mineralization in very low-birth-weight infants (28 to 32 weeks' gestation) was studied using infant-adapted direct photon absorptiometry. The 81 calories/dl experimental formula (Similac Special Care) contained 50% of the carbohydrate as Polycose, 50% of the fat as medium-chain triglycerides, and a whey:casein protein ratio of 60:40. It also contained large amounts of calcium (140 mg/dl), phosphorus (75 mg/dl), and vitamin D (120 IU/dl). Over a three- to five-week period, bone mineralization increased in two-thirds of the infants and decreased in the remainder, but all values remained in the range expected for bone mineral content in utero. Serum calcium, phosphate, magnesium, alkaline phosphatase, 25-hydroxy-vitamin D, and parathyroid hormone concentrations remained stable, whereas calcitonin concentrations fell.
F R Greer; J J Steichen; R C Tsang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  100     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  951-5     Citation Subset:  AIM; IM    
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MeSH Terms
Bone and Bones / metabolism*
Calcium / administration & dosage
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Infant Food*
Infant, Newborn
Infant, Premature*
Minerals / metabolism*
Phosphorus / administration & dosage
Triglycerides / administration & dosage
Vitamin D / administration & dosage
Grant Support
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Minerals; 0/Triglycerides; 1406-16-2/Vitamin D; 7440-70-2/Calcium; 7723-14-0/Phosphorus

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