| Effects of in vitro amiodarone exposure on alveolar macrophage inflammatory mediator production. | |
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MedLine Citation:
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PMID: 1333729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Administration of amiodarone, although often lifesaving, is associated with pulmonary side effects. Patients with amiodarone pulmonary toxicity can present with either a chronic disorder that suggests pulmonary fibrosis or a more acute process. Mechanisms of acute pulmonary injury resulting from amiodarone are unclear. Previous studies have demonstrated that the drug is preferentially concentrated in alveolar macrophages. In the present study, the authors examined whether in vitro exposure to amiodarone resulted in alteration of rat alveolar macrophage superoxide, leukotriene B4, or fibronectin release. In addition, the authors assessed whether macrophages were ultrastructurally altered by in vitro amiodarone exposure. Twenty four hour exposure to therapeutic tissue concentrations of amiodarone resulted in enhancement of phorbol myristate acetate-stimulated macrophage superoxide release. In addition, 48 hours exposure to amiodarone caused a dose-dependent inhibition of spontaneous fibronectin release by macrophages. Macrophages exposed to 48 hours of 10 micrograms/ml amiodarone were ultrastructurally abnormal, containing lamellar inclusions and demonstrating a large degree of vacuolization. The authors concluded that alveolar macrophages are very sensitive to therapeutic tissue concentrations of amiodarone. Alteration of macrophage mediator release by amiodarone may be one mechanism for lung damage induced by the drug. |
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Authors:
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R J Zitnik; J A Cooper; J A Rankin; J Sussman |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 304 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-01-06 Completed Date: 1993-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 352-6 Citation Subset: AIM; IM |
Affiliation:
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Pulmonary Section, Yale University School of Medicine, New Haven, Connecticut. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amiodarone
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adverse effects* Animals Cell Adhesion / drug effects Fibronectins / metabolism Inflammation / pathology Leukotriene B4 / metabolism Macrophages, Alveolar / drug effects*, metabolism, ultrastructure Male Microscopy, Electron Rats Superoxides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fibronectins; 11062-77-4/Superoxides; 1951-25-3/Amiodarone; 71160-24-2/Leukotriene B4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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