| Effects of in utero endotoxemia on the ovine fetal brain: A model for schizophrenia? | |
MedLine Citation:
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PMID: 22652683 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Infections during pregnancy can adversely affect the development of the fetal brain. This may contribute to disease processes such as schizophrenia in later life. Changes in the (cyto-) architecture of the anterior cingulate cortex (ACC), particularly in GABA-ergic interneurons, play a role in the pathogenesis of schizophrenia. We hypothesized that exposure to infection during pregnancy could result in cyto-architectural changes in the fetal ACC, similar to the pathogenesis seen in schizophrenia. Fetal sheep of 110 days GA (term=150 days GA) received an intravenous injection of 100ng or 500ng lipopolysaccharide (LPS) or saline as control. After delivery at 113 days GA, the cyto-architecture of the cingulate cortex (CC) was examined by immunohistochemistry. High dose LPS exposure resulted in a decreased density of GFAP-, calbindin D-28K- and parvalbumin-immunoreactive cells in the CC. In addition, these cells and calretinin-immunoreactive cells showed a changed morphology with reduced cell processes. This study provides further evidence that intra-uterine endotoxemia can induce changes in the fetal brain which correspond with changes seen in schizophrenia. |
Authors:
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Markus Gantert; Pawel Kreczmanski; Elke Kuypers; Reint Jellema; Eveline Strackx; Nina Bastian; Antonio Wd Gavilanes; Luc Ji Zimmermann; Yves Garnier; Christoph Schmitz; Boris W Kramer |
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Publication Detail:
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Type: Journal Article Date: 2012-06-01 |
Journal Detail:
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Title: Frontiers in bioscience (Elite edition) Volume: 4 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2012 |
Date Detail:
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Created Date: 2012-06-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 2845-53 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology Klinikum Osnabruck,Osnabruck, Germany. |
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