Document Detail

Effects of in utero endotoxemia on the ovine fetal brain: A model for schizophrenia?
MedLine Citation:
PMID:  22652683     Owner:  NLM     Status:  In-Data-Review    
Infections during pregnancy can adversely affect the development of the fetal brain. This may contribute to disease processes such as schizophrenia in later life. Changes in the (cyto-) architecture of the anterior cingulate cortex (ACC), particularly in GABA-ergic interneurons, play a role in the pathogenesis of schizophrenia. We hypothesized that exposure to infection during pregnancy could result in cyto-architectural changes in the fetal ACC, similar to the pathogenesis seen in schizophrenia. Fetal sheep of 110 days GA (term=150 days GA) received an intravenous injection of 100ng or 500ng lipopolysaccharide (LPS) or saline as control. After delivery at 113 days GA, the cyto-architecture of the cingulate cortex (CC) was examined by immunohistochemistry. High dose LPS exposure resulted in a decreased density of GFAP-, calbindin D-28K- and parvalbumin-immunoreactive cells in the CC. In addition, these cells and calretinin-immunoreactive cells showed a changed morphology with reduced cell processes. This study provides further evidence that intra-uterine endotoxemia can induce changes in the fetal brain which correspond with changes seen in schizophrenia.
Markus Gantert; Pawel Kreczmanski; Elke Kuypers; Reint Jellema; Eveline Strackx; Nina Bastian; Antonio Wd Gavilanes; Luc Ji Zimmermann; Yves Garnier; Christoph Schmitz; Boris W Kramer
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Publication Detail:
Type:  Journal Article     Date:  2012-06-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  4     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2845-53     Citation Subset:  IM    
Department of Obstetrics and Gynaecology Klinikum Osnabruck,Osnabruck, Germany.
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