| Effects of an improved auditory-periphery model on the response properties of modeled neurons in the dorsal cochlear nucleus. | |
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MedLine Citation:
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PMID: 19163205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dorsal Cochlear Nucleus (DCN) neurons were simulated using two different models of auditory nerve (AN) fibers as inputs, the Carney model [1] and the Zilany & Bruce model [2], [3]. The change of AN models produced very different responses. DCN neurons simulated using the Zilany and Bruce model had much greater regions of excitation and significantly reduced regions of inhibition. Further investigation into the differences between the two AN models revealed that the broadened tuning of the auditory nerve fibers produced by the Zilany & Bruce model at higher stimulus intensities coupled with the lower excitation thresholds accounted for the discrepancies. Changes in DCN model connection parameters and their effects on the resulting simulated neurons were then explored in an attempt to provide a qualitative framework for determining a set of DCN parameters capable of reproducing physiological responses using the Zilany and Bruce AN fiber model. A mix of increased W-cell inhibition to narrow the response of type-II cells and changes in AN connection parameters to increase their excitability at higher intensities were found to be required to reproduce physiological response properties. These changes in the type-II cell response would provide adequate compensation for the increased excitation and broadened responses at higher intensities observed in DCN model P-cells. |
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Authors:
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Stephen Vetsis; Xiaohan Zheng; Herbert F Voigt; Ian C Bruce |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Volume: 2008 ISSN: 1557-170X ISO Abbreviation: Conf Proc IEEE Eng Med Biol Soc Publication Date: 2008 |
Date Detail:
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Created Date: 2009-02-16 Completed Date: 2009-04-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101243413 Medline TA: Conf Proc IEEE Eng Med Biol Soc Country: United States |
Other Details:
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Languages: eng Pagination: 2477-80 Citation Subset: IM |
Affiliation:
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Dept of Electrical&Computer Engineering, McMaster University, Hamilton, ON, Canada. vetsiss@grads.ece.mcmaster.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Action Potentials Animals Auditory Pathways / pathology, physiopathology* Cats Cochlea / pathology, physiopathology* Cochlear Nerve / physiopathology* Cochlear Nucleus / pathology, physiopathology* Computer Simulation Hair Cells, Auditory / cytology Hearing Loss / pathology, physiopathology* Humans Interneurons / pathology Models, Neurological Neuronal Plasticity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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