| Effects of impressic acid from Acanthopanax koreanum on NF-κB and PPARγ activities. | |
| | |
MedLine Citation:
|
PMID: 21910057 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Impressic acid, 3α,11α-dihydroxylup-20(29)-en-28-oic acid, is a lupane-type triterpenoid isolated from Acanthopanax koreanum, which has been used as a Korean folk medicine for rheumatism, hepatitis, diabetes, and inflammatory disorders. Recently, it was reported that impressic acid has inhibitory effects on the LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells and on the nuclear factor of activated T-cells transcription factor activity. Thus, to investigate whether impressic acid has effects on the inhibition of nuclear factor kappa B (NF-κB) and activation of peroxisome proliferator-activated receptor gamma (PPARγ), luciferase reporter assays were used. The effects on the expression of NF-κB and PPARγ target genes were also examined by reverse transcription-polymerase chain reaction. In this study, impressic acid was found to inhibit tumor necrosis factor (TNF)-α induced NF-κB activity and to up-regulate transcriptional activity of PPARγ. |
| | |
Authors:
|
Jeong Ah Kim; Seo Young Yang; Seok Bean Song; Young Ho Kim |
Related Documents
:
|
2918947 - Effects of l-carnitine administration on short-chain fatty acid (acetic acid) and long-... 12957477 - Divergence of endocrine and metabolic responses to stress in two rainbow trout lines se... 6655567 - A renal mechanism for the clofibric acid-probenecid interaction. 15169967 - Role of fatty acid composition in the development of metabolic disorders in sucrose-ind... 8347827 - Iron(iii) chloride injection increases nigral uric acid in guinea-pig. 12018617 - Structural and functional characterization of basic pla2 isolated from crotalus durissu... |
Publication Detail:
|
Type: Journal Article Date: 2011-09-11 |
Journal Detail:
|
Title: Archives of pharmacal research Volume: 34 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-09-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
|
Languages: eng Pagination: 1347-51 Citation Subset: IM |
Affiliation:
|
College of Pharmacy, Chungnam National University, Daejeon, 305-764, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of saucerneol D on melanin production in cAMP-elevated melanocytes.
Next Document: Antimicrobial activity of commonly used antibiotics and DNA fingerprint analysis of Pseudomonas aeru...