| Effects of immunoadsorption and subsequent immunoglobulin G substitution on cardiopulmonary exercise capacity in patients with dilated cardiomyopathy. | |
| | |
MedLine Citation:
|
PMID: 20435190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Recent data indicate that cardiac antibodies play an active role in the pathogenesis of dilated cardiomyopathy (DCM) and may contribute to cardiac dysfunction in patients with DCM. The present study investigated the influence of immunoadsorption with subsequent immunoglobulin G substitution (IA/IgG) on cardiopulmonary exercise capacity in patients with DCM. METHODS: Sixty patients with DCM (New York Heart Association II-IV, left ventricular ejection fraction < or =45%) were included in this single-center university hospital-based case-control study. Patients either were treated with IA/IgG (n = 30) or were followed without IA/IgG (n = 30). At baseline and after 3 months, we compared echocardiographic assessment of left ventricular function and spiroergometric exercise parameters. RESULTS: In contrast to controls, left ventricular ejection fraction improved significantly in the IA/IgG group from 33.0% +/- 1.2% to 40.1% +/- 1.5% (P < .001). In the control group, spiroergometric exercise parameters did not change during follow-up. After 3 months, maximum achieved power increased in the treatment group from 114.2 +/- 7.4 to 141.9 +/- 7.9 W (P = .02). Total exercise time increased in the treatment group from 812 +/- 29 to 919 +/- 30 seconds (P < .05). Peak oxygen uptake (Vo(2)) increased from 17.3 +/- 0.9 to 21.8 +/- 1.0 mL min(-1) kg(-1) after IA/IgG (P < .01). Oxygen pulse (peak Vo(2)/maximum heart rate) increased in the treatment group (10.7 +/- 0.7 vs 13.6 +/- 0.7 mL beat(-1) min(-1), P < .01). The Vo(2) at the gas exchange anaerobic threshold increased after 3 months in the treatment group from 10.3 +/- 0.5 to 13.2 +/- 0.5 mL min(-1) kg(-1) (P < .001). The ventilatory response to exercise (V(E)/Vco(2) slope) decreased after IA/IgG therapy from 32.3 +/- 1.5 to 28.7 +/- 0.9 (P = .02). CONCLUSIONS: In patients with DCM, IA/IgG therapy may induce improvement in echocardiographic and cardiopulmonary exercise parameters. |
| | |
Authors:
|
Lars R Herda; Christiane Trimpert; Ute Nauke; Martin Landsberger; Astrid Hummel; Daniel Beug; Arne Kieback; Marcus D?rr; Klaus Empen; Fabian Knebel; Ralf Ewert; Aniela Angelow; Wolfgang Hoffmann; Stephan B Felix; Alexander Staudt |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American heart journal Volume: 159 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-03 Completed Date: 2010-05-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
|
Languages: eng Pagination: 809-16 Citation Subset: AIM; IM |
Copyright Information:
|
2010 Mosby, Inc. All rights reserved. |
Affiliation:
|
Klinik f?r Innere Medizin B, Ernst-Moritz-Arndt-Universit?t, Greifswald, Germany. herda@uni-greifswald.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cardiomyopathy, Dilated
/
immunology*,
therapy Case-Control Studies Electrocardiography Ergometry Exercise Test Exercise Tolerance / immunology* Female Heart Failure / drug therapy Humans Immunoglobulin G / blood* Immunosorbent Techniques Male Middle Aged Oxygen Consumption Plethysmography, Whole Body Stroke Volume / physiology Surface Plasmon Resonance |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased risk for coronary heart disease after avascular necrosis of femoral head: A 3-year follow-...
Next Document: Association of Health Aging and Body Composition (ABC) Heart Failure score with cardiac structural a...