Document Detail


Effects of iloprost, a PGI2 derivative, on ischemic myocardial energy and carbohydrate metabolism in dogs.
MedLine Citation:
PMID:  7681140     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of iloprost, which is a stable prostacyclin analogue, on the ischemic myocardium were examined in the open-chest dog heart in terms of biochemical parameters. Ischemia was initiated by ligating the left anterior descending coronary artery. When the coronary artery was ligated for 3 min, the levels or glycogen, fructose-1,6-diphosphate (FDP), adenosine triphosphate and creatine phosphate decreased, and the levels of glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), lactate, adenosine diphosphate and adenosine monophosphate increased. During ischemia, therefore, energy charge potential was significantly decreased from 0.89 +/- 0.01 to 0.82 +/- 0.01, and ([G6P] + [F6P])/[FDP] and [lactate]/[pyruvate] ratios were significantly increased from 1.75 +/- 0.30 to 29.05 +/- 5.70 and 13 +/- 3 to 393 +/- 112, respectively. Iloprost (0.1, 0.3, or 1 microgram.kg-1) was injected intravenously 5 min before the onset of ischemia. Iloprost (0.1, 0.3, and 1 micrograms.kg-1) reduced the ischemia-induced decrease in energy charge potential to 94, 74, and 86%, respectively, the increase in ([G6P] + [F6P])/[FDP] to 38, 29, 32%, respectively, and the increase in [lactate]/[pyruvate] to 67, 45, 65%, respectively. These results suggest that iloprost lessens the myocardial metabolic derangements produced by ischemia, and the most potent effect was obtained at the dose of 0.3 microgram.kg-1.
Authors:
K Ichihara; K Yamamoto; Y Abiko
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  119     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-20     Completed Date:  1993-04-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  133-41     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Asahikawa Medical College, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / metabolism
Animals
Dogs
Energy Metabolism / drug effects
Female
Fructosediphosphates / metabolism
Glucose-6-Phosphate
Glucosephosphates / metabolism
Glycogen / metabolism
Heart / drug effects*
Hemodynamics / drug effects
Iloprost / pharmacology*
Lactates / metabolism
Male
Myocardial Ischemia / drug therapy*
Phosphocreatine / metabolism
Chemical
Reg. No./Substance:
0/Fructosediphosphates; 0/Glucosephosphates; 0/Lactates; 488-69-7/fructose-1,6-diphosphate; 56-73-5/Glucose-6-Phosphate; 58-64-0/Adenosine Diphosphate; 67-07-2/Phosphocreatine; 78919-13-8/Iloprost; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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