Document Detail


Effects of ibopamine on exercise-induced increase in norepinephrine in normal men.
MedLine Citation:
PMID:  1378116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of 100 mg ibopamine, an orally active aselective dopamine (DA) agonist, on plasma catecholamines was evaluated in 8 healthy men during sympathetic stimulation by graded exercise in a single-blind, placebo-controlled cross-over study. The exercise consisted of progressive cycling activity less than or equal to 90% of the previously determined VO2max. Graded exercise resulted in an increase in systolic and mean blood pressure (SBP, MBP), heart rate, norepinephrine (NE) and epinephrine level, with a decrease in diastolic BP (DBP). The increase in NE was significantly blunted by ibopamine as compared with placebo. No differences for BP, heart rate (HR), or epinephrine between placebo- and ibopamine study day were noted. In previous studies, ibopamine decreased resting plasma NE in patients with congestive heart failure (CHF), whereas plasma NE was not altered by ibopamine in healthy volunteers. This different outcome in both categories might therefore be explained by the absence of substantial sympathetic stimulation in normal humans at rest. Because it is reasonable to assume that the effect of ibopamine on systemic and local hemodynamics is negligible as compared with the effect of exercise in the healthy volunteers, the plasma decrease caused by ibopamine is probably related to stimulation of DA2-receptors. In conclusion, ibopamine blunts the increase of plasma NE during graded exercise in healthy men.
Authors:
A R Girbes; D J Van Veldhuisen; R G Grevink; A J Smith; W D Reitsma
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  19     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-08-10     Completed Date:  1992-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  371-4     Citation Subset:  IM    
Affiliation:
Department of Surgery, University Hospital Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism
Blood Pressure / drug effects
Deoxyepinephrine / analogs & derivatives*,  blood,  metabolism,  pharmacology
Dopamine Agents / adverse effects,  pharmacology*
Drug Administration Schedule
Epinephrine / blood
Exercise / physiology*
Heart Rate / drug effects
Humans
Male
Norepinephrine / blood*
Single-Blind Method
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dopamine Agents; 501-15-5/Deoxyepinephrine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 66195-31-1/ibopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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