Document Detail

Effects of ibopamine on acute cardiac failure following experimental coronary occlusion in dogs.
MedLine Citation:
PMID:  3707644     Owner:  NLM     Status:  MEDLINE    
The activity of ibopamine (SB-7505), the 3,4-diisobutyryl ester of N-methyldopamine, on myocardial contractility and systemic and renal hemodynamics was investigated in the anesthetized dog with experimental infarction, instrumented with catheters and electromagnetic flowmeters. Ibopamine, given by the intraduodenal route at a dose of 24 mg/kg, was effective in improving the hemodynamic parameters depressed by myocardial infarction, in particular myocardial contractility and renal hemodynamics. In eliciting such activity which resembles that developed by dopamine in similar experimental conditions, ibopamine seems to meet the requirements of an orally active pharmacological agent useful in the therapy of acute heart failure.
G Marchetti; L Merlo
Related Documents :
25450324 - Right ventricular infarction and mitral stenosis: a resuscitation challenge.
25355394 - Poincare indices for analyzing meditative heart rate signals.
22129964 - Imbalance of arginine and asymmetric dimethylarginine is associated with markers of cir...
25302484 - Development of a multiparametric score to predict left ventricular remodelling and prog...
15870414 - Tirofiban and sirolimus-eluting stent vs abciximab and bare-metal stent for acute myoca...
18549934 - Interleukin-6 and neutrophils are associated with long-term survival after acute myocar...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  36     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-05-28     Completed Date:  1986-05-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  331-3     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiotonic Agents / pharmacology*
Coronary Disease / complications*
Deoxyepinephrine / analogs & derivatives*,  pharmacology
Dopamine / analogs & derivatives*,  pharmacology
Heart Failure / drug therapy*,  etiology,  physiopathology
Hemodynamics / drug effects
Reg. No./Substance:
0/Cardiotonic Agents; 501-15-5/Deoxyepinephrine; 66195-31-1/ibopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Activity of ibopamine on central nervous system in mice and rats.
Next Document:  Ibopamine, an orally active dopamine-like drug: metabolism and pharmacokinetics in rats.