Document Detail


Effects of ibopamine on acute cardiac failure following experimental coronary occlusion in dogs.
MedLine Citation:
PMID:  3707644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activity of ibopamine (SB-7505), the 3,4-diisobutyryl ester of N-methyldopamine, on myocardial contractility and systemic and renal hemodynamics was investigated in the anesthetized dog with experimental infarction, instrumented with catheters and electromagnetic flowmeters. Ibopamine, given by the intraduodenal route at a dose of 24 mg/kg, was effective in improving the hemodynamic parameters depressed by myocardial infarction, in particular myocardial contractility and renal hemodynamics. In eliciting such activity which resembles that developed by dopamine in similar experimental conditions, ibopamine seems to meet the requirements of an orally active pharmacological agent useful in the therapy of acute heart failure.
Authors:
G Marchetti; L Merlo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  36     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-05-28     Completed Date:  1986-05-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  331-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiotonic Agents / pharmacology*
Coronary Disease / complications*
Deoxyepinephrine / analogs & derivatives*,  pharmacology
Dogs
Dopamine / analogs & derivatives*,  pharmacology
Electrocardiography
Female
Heart Failure / drug therapy*,  etiology,  physiopathology
Hemodynamics / drug effects
Male
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 501-15-5/Deoxyepinephrine; 66195-31-1/ibopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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