Document Detail

Effects of ibogaine on naloxone-precipitated withdrawal in morphine-dependent mice.
MedLine Citation:
PMID:  1292965     Owner:  NLM     Status:  MEDLINE    
In naive mice, ibogaine at a tremorigenic dose (30 mg/kg, ip), did not produce antinociception but did potentiate the antinociceptive potency of morphine in the tail-flick test. In morphine-dependent mice, ibogaine did not eliminate withdrawal symptoms but significantly increased the number of repetitive vertical jumps induced by naloxone, whatever the duration of the chronic morphine treatment. By comparison, repetitive jumping induced by alpha-napthoxyacetic acid (alpha-NOAA), a non-convulsant drug which induced jumping without affecting other morphine-withdrawal signs, was not significantly modified by ibogaine. These results indicate that while acute antinociceptive effects of morphine are modulated by ibogaine, this drug, shown to alleviate opiate dependence in man, does not attenuate in mice opioid withdrawal manifestations.
B Francés; R Gout; J Cros; J M Zajac
Related Documents :
3380255 - Effect of acute arecoline, tacrine and arecoline + tacrine post-training administration...
2345555 - Evaluation of genotoxicity of clofazimine, an antileprosy drug, in mice in vivo. ii. mi...
10536295 - Chemotherapy for enterohemorrhagic escherichia coli o157:h infection in a mouse model.
25367805 - Association between contraband tobacco and illicit drug use among high school students ...
18363145 - Assessment of drug release from oil depot formulations using an in vitro model -- poten...
19696225 - Esrd impairs nonrenal clearance of fexofenadine but not midazolam.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  6     ISSN:  0767-3981     ISO Abbreviation:  Fundam Clin Pharmacol     Publication Date:  1992  
Date Detail:
Created Date:  1993-04-08     Completed Date:  1993-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  327-32     Citation Subset:  IM    
Laboratoire de Pharmacologie et de Toxicologie Fondamentales, CNRS, Toulouse, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Drug Synergism
Ibogaine / pharmacology*
Morphine / pharmacology
Morphine Dependence*
Naloxone / pharmacology*
Pain Measurement
Substance Withdrawal Syndrome*
Reg. No./Substance:
465-65-6/Naloxone; 57-27-2/Morphine; 83-74-9/Ibogaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinicopathological study on the proliferation and differentiation of laryngeal carcinoma and dyspla...
Next Document:  Inhibition of [3H] gamma-aminobutyric acid release from guinea-pig hippocampal synaptosomes by serot...