Document Detail


Effects of ibogaine on naloxone-precipitated withdrawal in morphine-dependent mice.
MedLine Citation:
PMID:  1292965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In naive mice, ibogaine at a tremorigenic dose (30 mg/kg, ip), did not produce antinociception but did potentiate the antinociceptive potency of morphine in the tail-flick test. In morphine-dependent mice, ibogaine did not eliminate withdrawal symptoms but significantly increased the number of repetitive vertical jumps induced by naloxone, whatever the duration of the chronic morphine treatment. By comparison, repetitive jumping induced by alpha-napthoxyacetic acid (alpha-NOAA), a non-convulsant drug which induced jumping without affecting other morphine-withdrawal signs, was not significantly modified by ibogaine. These results indicate that while acute antinociceptive effects of morphine are modulated by ibogaine, this drug, shown to alleviate opiate dependence in man, does not attenuate in mice opioid withdrawal manifestations.
Authors:
B Francés; R Gout; J Cros; J M Zajac
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  6     ISSN:  0767-3981     ISO Abbreviation:  Fundam Clin Pharmacol     Publication Date:  1992  
Date Detail:
Created Date:  1993-04-08     Completed Date:  1993-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  327-32     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacologie et de Toxicologie Fondamentales, CNRS, Toulouse, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Synergism
Ibogaine / pharmacology*
Mice
Morphine / pharmacology
Morphine Dependence*
Naloxone / pharmacology*
Pain Measurement
Substance Withdrawal Syndrome*
Chemical
Reg. No./Substance:
465-65-6/Naloxone; 57-27-2/Morphine; 83-74-9/Ibogaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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