| Effects of iatrogenic hypercortisolism on gallbladder sludge formation and biochemical bile constituents in dogs. | |
| | |
MedLine Citation:
|
PMID: 21316991 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
An association between gallbladder mucoceles and hypercortisolism (HC) was recently described in dogs. Because the formation of a mucocele from clear bile without the transitional formation of microprecipitates appears unlikely, the aim of this study was to investigate the effects of iatrogenic HC on sludge formation and changes in the biochemical composition of bile. Bile samples from 6 dogs obtained by percutaneous ultrasound-guided cholecystocentesis before (day 0), during (days 28, 56, and 84), and after (days 28p, 56p, and 84p) oral administration of hydrocortisone (8mg/kg every12h) were analysed for calcium, cholesterol and bilirubin concentrations and pH. In addition the gallbladder was examined ultrasonographically for sludge. Six dogs receiving a placebo served as controls. Although gallbladder sludge was observed in all treated dogs at day 56, it was also noted in 50% of control dogs, and no significant differences were seen between groups at any sampling time. Bilirubin and cholesterol concentrations decreased significantly and reversibly during treatment, and calcium concentration showed a similar trend. Bile pH was consistently slightly alkaline during iatrogenic HC, whereas it was slightly acidic in control animals. A 3-month period of iatrogenic HC does not lead to ultrasonographically detectable gallbladder sludge or to an increase in bile constituents that are commonly implicated in sludge formation in humans. |
| | |
Authors:
|
P H Kook; S Schellenberg; K M Rentsch; C E Reusch; T M Glaus |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-11 |
Journal Detail:
|
Title: Veterinary journal (London, England : 1997) Volume: - ISSN: 1532-2971 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9706281 Medline TA: Vet J Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Surgical hand antisepsis in veterinary practice: Evaluation of soap scrubs and alcohol based rub tec...
Next Document: A retrospective study of serum ?-hydroxybutyric acid in 215 ill cats: Clinical signs, laboratory fin...