Document Detail


Effects of hysterectomy on ovulation and related ovarian functions in regular estrous cycle rats.
MedLine Citation:
PMID:  8007765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The number of ovulation was significantly higher in hysterectomized rats with regular estrous cycles than in sham-operated rats at the estrous stage 20-24 days after operations (13.2 +/- 0.33 vs. 11.8 +/- 0.41, P < 0.05). This finding suggests that hysterectomy facilitates the follicular maturation in rats. To examine the mechanism of facilitation on follicular maturation in hysterectomized rats, plasma FSH level, ovarian estradiol-17 beta (E2) and ovarian aromatase activity were measured 20 days after hysterectomy. Hysterectomy had no effect on plasma FSH levels at any of the estrous stages. Ovarian E2 level and aromatase activity (AA) were significantly increased by hysterectomy only at diestrus-2 stage of the estrous cycle (E2; 3.76 +/- 0.49 vs. 1.48 +/- 0.49 ng/g ovarian tissue, P < 0.05, AA; 1.36 +/- 0.15 vs. 0.83 +/- 0.11 pmol/h. mg ovarian tissue, P < 0.05), but ovarian testosterone level was not affected by the operation. These results support the hypothesis that in rats hysterectomy facilitates follicular maturation. This may be due to an increase in ovarian E2 level at the diestrus-2 stage, caused by heightened ovarian aromatase activity.
Authors:
M Tanaka; T Kumai; M Watanabe; C Matsumoto; M Hirai; S Kobayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  55     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1994  
Date Detail:
Created Date:  1994-07-19     Completed Date:  1994-07-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  237-43     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, St. Marianna University School of Medicine, Kanagawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aromatase / metabolism
Diestrus / physiology
Estradiol / metabolism
Estrus / physiology*
Female
Follicle Stimulating Hormone / blood
Hysterectomy*
Ovary / metabolism,  physiology*
Ovulation*
Rats
Rats, Wistar
Testosterone / metabolism
Chemical
Reg. No./Substance:
50-28-2/Estradiol; 58-22-0/Testosterone; 9002-68-0/Follicle Stimulating Hormone; EC 1.14.14.1/Aromatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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