Document Detail

Effects of hypoventilation on the cardiovascular responses of rats to adrenaline and acetylcholine.
MedLine Citation:
PMID:  4011669     Owner:  NLM     Status:  MEDLINE    
Blood pressure and pulse rate in response to administered adrenaline and acetylcholine during hypoventilation were studied in urethane-anaesthetized rats. Hypoventilation was induced by decreasing the stroke volume of artificial ventilation from 1 ml/100 g to 0.3 ml/100 g. There was a significant rise in pulse rate accompanied by minimal changes in blood pressure during hypoventilation. The blood pressure and pulse rate in response to adrenaline were significantly reduced. The depressant effect of acetylcholine on pulse rate was intensified, but that on blood pressure was not significantly affected. These findings suggest that the compensatory cardiovascular reflexes may be impaired during hypoventilation.
S Dai; Y H Wong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology     Volume:  30     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1985  
Date Detail:
Created Date:  1985-08-22     Completed Date:  1985-08-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  314-9     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / pharmacology*
Blood Pressure / drug effects
Epinephrine / pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypoventilation / physiopathology*
Rats, Inbred Strains
Reg. No./Substance:
51-43-4/Epinephrine; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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