| Effects of hypothyroidism on the structural development of the organ of Corti in the rat. | |
| | |
MedLine Citation:
|
PMID: 7315266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The structural development of the organ of Corti was studied in 30 rat pups rendered hypothyroid by daily administration of propylthiouracil during the first 35 days after birth. Cochlear changes were observed by light microscopy and electronmicroscopy. Hypothyroid rat pups were found to have severe abnormalities in the organ of Corti. There was an abnormally prolonged persistence of Kölliker's organ and striking distortion of the tectorial membrane. The sensory epithelium exhibited marked signs of immaturity: the tunnel of Corti has not opened yet in animals 35 days old, sensory and supporting cells presented immature characteristics with abnormal persistence of the kinocilium. It is suggested that hypothyroidism results in an overall retardation of the maturation of cochlear structures and ultrastructural changes that appear to be significant enough to account for the hearing loss. |
| | |
Authors:
|
A Uziel; J Gabrion; M Ohresser; C Legrand |
Related Documents
:
|
9876046 - Rat embryonic hippocampal neurons express a new class a calcium channel variant. 4041916 - Postnatal neurogenesis in the rat hypothalamus. 16369776 - Sonic hedgehog expression in the development of hindgut in etu-exposed fetal rats. 2268066 - The cranial venous system in the rat: anatomical pattern and ontogenetic development. i... 16546836 - Isolated heart function after ischemia and reperfusion in sucrose-fed rats: influence o... 2007356 - Inhibition of iron absorption by omeprazole in rat model. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta oto-laryngologica Volume: 92 ISSN: 0001-6489 ISO Abbreviation: Acta Otolaryngol. Publication Date: 1981 Nov-Dec |
Date Detail:
|
Created Date: 1982-02-25 Completed Date: 1982-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: SWEDEN |
Other Details:
|
Languages: eng Pagination: 469-80 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Deafness / etiology Female Hypothyroidism / chemically induced, complications* Microscopy, Electron Organ of Corti / pathology*, ultrastructure Pregnancy Propylthiouracil Rats |
| Chemical | |
Reg. No./Substance:
|
51-52-5/Propylthiouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Deviation with increasing age in histologic appearance of submucosal glands in human eustachian tube...
Next Document: Eustachian tube function in normal children and adults.