Document Detail

Effects of hypothyroidism on pregnancy of rats.
MedLine Citation:
PMID:  7380526     Owner:  NLM     Status:  MEDLINE    
Adult female rats of approximately same age and weight were grouped and thyroidectomized before pregnancy and at different stages of gestation. While studying their pregnancy performances, it was observed that there was a significant (P less than 0.05) increase in the length of gestation in thyroidectomized animals as compared to intact controls. This is possibly due to the smaller litter size. The litter size and foetal weights were significantly (P less than 0.01) lower than the controls and were inversely proportional to the duration of the hypothyroidism during pregnancy. Hypothyroidism did not affect the implantation. The mammary gland growth was significantly (P less than 0.01) reduced in all the experimental groups. Hypothyroidism during pregnancy hardly affected the adrenal weight but significantly (P less than 0.01) decreased the ovarian weight possibly due to the disturbance in hypophysialgonadal axis.
P M Rao; J N Panda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  24     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:    1980 Apr-Jun
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  126-30     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / anatomy & histology
Fetal Death / etiology
Fetal Resorption / etiology
Fetus / anatomy & histology
Hypothyroidism / physiopathology*
Mammary Glands, Animal / anatomy & histology
Organ Size
Ovary / anatomy & histology
Pregnancy Complications / physiopathology*
Thyroid Hormones / physiology
Time Factors
Reg. No./Substance:
0/Thyroid Hormones

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