| Effects of hypothermia on ischaemic depolarisation in brain : a comparison of responses in rat and gerbil. | |
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MedLine Citation:
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PMID: 15375440 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The latency of development of ischaemic depolarization (LID) has been used to compare the relative effects of different levels of hypothermia on ischaemic responses in brains of rat and gerbil, using a model with imposed complete cessation of cerebral blood flow (CBF=0). At temperatures reducing from 37 degrees C to 20 degrees C, the LIDs were consistently shorter in the gerbil than in the rat. For example, at 37 degrees C the LID in the gerbil was 0.71+/- 01.2 min, and in the rat, 1.37 +/- 0.02 min respectively (P<0.01), whilst at 20 degrees C, the values were 5.48 +/- 0.25 min and 7.30 +/- 0.76 min (P<0.01). However, the relative effects of hypothermia on each species were similar (by linear regression with slopes of -0.29 and -0.35 min/degree C in the two species). There may be underlying differences in brain biophysics or structure between species, but in spite of this, applied hypothermia still imposes a similar depression on the development of ischaemic damage. Both models may thus be used in studies of brain hypothermia as long as the intrinsic differences are appreciated. |
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Authors:
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Barry Fuller; Edward Proctor |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cryo letters Volume: 25 ISSN: 0143-2044 ISO Abbreviation: Cryo Letters Publication Date: 2004 Jul-Aug |
Date Detail:
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Created Date: 2004-09-17 Completed Date: 2005-01-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9891832 Medline TA: Cryo Letters Country: England |
Other Details:
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Languages: eng Pagination: 301-6 Citation Subset: IM |
Affiliation:
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University Department of Surgery, Royal Free and UC Medical School, Pond Street, London NW3 2QG, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / blood supply* Cerebrovascular Circulation Gerbillinae Hypothermia / physiopathology* Hypoxia-Ischemia, Brain / physiopathology* Male Rats Rats, Sprague-Dawley |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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