| Effects of hypothermia on drug absorption. | |
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MedLine Citation:
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PMID: 3509290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The in situ rat gut technique was used to study the effects of hypothermia on the intestinal absorption of a 1 mg/ml solution of sodium pentobarbital in 0.01 M phosphate buffer (pH 6.0). Male Sprague-Dawley rats weighing between 300 and 370 g were exposed to an atmosphere of helox (helium:oxygen, 80:20) at 0-4 degrees C for 5 hr. This procedure lowers the rectal temperature of the rats from 38 to 20 degrees C. The animals were prepared for surgery using ether as anesthetic after their rectal temperature reached 20 degrees C. Water flux in and out of the intestinal lumen was estimated from tritiated polyethylene glycol 4000 concentrations in the perfusate. The disappearance rate constant of pentobarbital from the intestinal lumen was 0.0638 +/- 0.007 min-1 for hypothermic rats, in comparison to 0.114 +/- 0.0123 min-1 for normothermic rats. |
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Authors:
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S Stavchansky; I L Tung |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmaceutical research Volume: 4 ISSN: 0724-8741 ISO Abbreviation: Pharm. Res. Publication Date: 1987 Jun |
Date Detail:
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Created Date: 1989-09-14 Completed Date: 1989-09-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8406521 Medline TA: Pharm Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 248-50 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Pharmaceutics Division, University of Texas, Austin 78712. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Hypothermia / metabolism* Intestinal Absorption Intestines / metabolism* Male Pentobarbital / metabolism, pharmacokinetics* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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