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Effects of hypothermia on NSE and S-100 protein levels in CSF in neonates following hypoxic-ischemic brain damage.
MedLine Citation:
PMID:  22452413     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim  The aim of the study was to evaluate the effects of hypothermia on neuron-specific enolase (NSE) and S-100 protein levels in cerebrospinal fluid (CSF) in neonates with hypoxic-ischemic encephalopathy (HIE). Methods  Fifty-one enrolled neonates with HIE were divided into two groups: hypothermia (n=23) and control (n=28). NSE and S-100 protein were measured with immunoradiometric assays. Amino acid neurotransmitters were also measured by reversed phase high-performance liquid chromatography. Neurodevelopmental assessments were performed at 3 and 12 months old. Results  NSE and S-100 levels were lower and neurodevelopment outcome was better in the hypothermia group compared with the control group. Among the infants who received hypothermia, CSF NSE and S-100 were significantly higher in those who developed severe neurological impairment (mental development index or physical development index <70). There were no significant differences between the two groups in amino acid neurotransmitters. Conclusion  These results indicated that hypothermia was associated with decreased CSF NSE and S-100 level and correlated with neurodevelopmental outcome in infants with HIE. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Authors:
Jinqiao Sun; Jin Li; Guoqiang Cheng; Bin Sha; Wenhao Zhou
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-27
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s)/Acta P&aelig;diatrica © 2012 Foundation Acta P&aelig;diatrica.
Affiliation:
Department of Clinical Immunology, Children's Hospital of Fudan University, China Key Laboratory of Neonatal Disease, Ministry of Health, China Institutes of Biomedical Sciences, Fudan University, China Department of Neonatology, Children's Hospital of Fudan University, China.
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