Document Detail

Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women.
MedLine Citation:
PMID:  15070939     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine whether a hypocaloric diet with and without exercise training is effective in reducing plasma C-reactive protein, IL-6, TNFalpha, and their soluble receptors (sIL-6R, sTNFR1, and sTNFR2), and whether changes in these inflammatory markers are related to changes in regional lipolysis in obese (body mass index, 32.78 +/- 4.73) postmenopausal women (diet alone, n = 17; diet plus exercise, n = 17). All inflammatory markers were measured by an ELISA method. In vitro lipolysis was evaluated by measuring glycerol release using a one-step enzymatic fluorometric technique. Six months of diet and diet plus exercise decreased total and abdominal fat to a similar degree. Diet plus exercise, but not diet alone, decreased plasma levels of C-reactive protein, IL-6, sIL-6R, and sTNFR1 and increased basal and postreceptor stimulated lipolysis in both abdominal and gluteal regions. Changes in abdominal stimulated lipolysis correlated significantly with changes in plasma IL-6 (r = -0.39) and TNFR1 (r = -047). Thus, diet plus exercise training, but not diet alone, is effective in reducing chronic inflammation in obese postmenopausal women. In addition, modification of chronic inflammation is associated with changes in local adipose tissue metabolism in response to diet and exercise.
Tongjian You; Dora M Berman; Alice S Ryan; Barbara J Nicklas
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  89     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-08     Completed Date:  2004-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1739-46     Citation Subset:  AIM; IM    
Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
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MeSH Terms
Adipocytes / metabolism*
Biological Markers / blood
Body Mass Index
Cytokines / blood
Diet, Reducing*
Enzyme-Linked Immunosorbent Assay
Inflammation Mediators / blood*
Middle Aged
Obesity / diet therapy*,  metabolism,  pathology
Physical Education and Training*
Grant Support
K01-AG00685/AG/NIA NIH HHS; K01-AG00747/AG/NIA NIH HHS; P30-AG21332/AG/NIA NIH HHS; P60-12583//PHS HHS; R01-AG/DK20583/AG/NIA NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Inflammation Mediators
Erratum In:
J Clin Endocrinol Metab.2004 Jun;89(6):2972

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