Document Detail


Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women.
MedLine Citation:
PMID:  15070939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine whether a hypocaloric diet with and without exercise training is effective in reducing plasma C-reactive protein, IL-6, TNFalpha, and their soluble receptors (sIL-6R, sTNFR1, and sTNFR2), and whether changes in these inflammatory markers are related to changes in regional lipolysis in obese (body mass index, 32.78 +/- 4.73) postmenopausal women (diet alone, n = 17; diet plus exercise, n = 17). All inflammatory markers were measured by an ELISA method. In vitro lipolysis was evaluated by measuring glycerol release using a one-step enzymatic fluorometric technique. Six months of diet and diet plus exercise decreased total and abdominal fat to a similar degree. Diet plus exercise, but not diet alone, decreased plasma levels of C-reactive protein, IL-6, sIL-6R, and sTNFR1 and increased basal and postreceptor stimulated lipolysis in both abdominal and gluteal regions. Changes in abdominal stimulated lipolysis correlated significantly with changes in plasma IL-6 (r = -0.39) and TNFR1 (r = -047). Thus, diet plus exercise training, but not diet alone, is effective in reducing chronic inflammation in obese postmenopausal women. In addition, modification of chronic inflammation is associated with changes in local adipose tissue metabolism in response to diet and exercise.
Authors:
Tongjian You; Dora M Berman; Alice S Ryan; Barbara J Nicklas
Related Documents :
19875999 - Pericardial fat volume correlates with inflammatory markers: the framingham heart study.
20467419 - Vertebral bone marrow fat is positively associated with visceral fat and inversely asso...
20359719 - Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated posi...
20616609 - Impact of walking on adipose tissue lipoprotein lipase activity and expression in pre- ...
10593529 - Physical activity and weight gain and fat distribution changes with menopause: current ...
20467889 - Central adiposity rather than total adiposity measurements are specifically involved in...
19875999 - Pericardial fat volume correlates with inflammatory markers: the framingham heart study.
25213789 - Effects of lipid-lowering pharmaceutical clofibrate on lipid and lipoprotein metabolism...
2145499 - A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  89     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-08     Completed Date:  2004-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1739-46     Citation Subset:  AIM; IM    
Affiliation:
Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. tyou@wfubmc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adipocytes / metabolism*
Biological Markers / blood
Body Mass Index
Cytokines / blood
Diet, Reducing*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Inflammation Mediators / blood*
Lipolysis*
Middle Aged
Obesity / diet therapy*,  metabolism,  pathology
Physical Education and Training*
Postmenopause*
Grant Support
ID/Acronym/Agency:
K01-AG00685/AG/NIA NIH HHS; K01-AG00747/AG/NIA NIH HHS; P30-AG21332/AG/NIA NIH HHS; P60-12583//PHS HHS; R01-AG/DK20583/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Inflammation Mediators
Comments/Corrections
Erratum In:
J Clin Endocrinol Metab.2004 Jun;89(6):2972

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients wit...
Next Document:  Hyperparathyroidism-jaw tumor syndrome in Roma families from Portugal is due to a founder mutation o...