| Effects of hypertonic saline-dextran solution on regional blood flow and thrombogenicity in PTFE grafts in the vena cava of the rabbit. | |
| | |
MedLine Citation:
|
PMID: 10706829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: to study the effects of hypervolaemic haemodilution with hypertonic saline-dextran solution (HSD) on regional blood flow and thrombogenicity of small diameter polytetrafluoroethylene (PTFE) grafts. DESIGN: blood flow in rabbit aorta, vena cava and femoral, renal and ear arteries was determined in five groups: controls, isovolaemic haemodilution with dextran-70 (10 ml/kg body weight (b.w. )), hypervolaemic haemodilution (10 ml/kg b.w.) with either dextran-70, 7.5% NaCl or a combination of dextran and NaCl (HSD). In a second series PTFE grafts were inserted into the vena cava of rabbits treated with hypervolaemic haemodilution with dextran, hypertonic saline or HSD and examined after two days. RESULTS: blood flow increased in aorta, vena cava and femoral artery after haemodilution. The increase was transient in animals treated with hypertonic NaCl alone but sustained in the dextran-70 groups. The grafts from animals treated with hypertonic saline alone had a lower thrombus mass and higher blood flow compared to those from rabbits haemodiluted with dextran-70 only, indicating that both dextran and NaCl have antithrombotic effects. Superior results were obtained with HSD solution. CONCLUSIONS: HSD solution has a strong flow-promoting action in several vascular beds and beneficial effects on the patency of small diameter vessel grafts. |
| | |
Authors:
|
L Frost-Arner; D Bergqvist |
Related Documents
:
|
8096689 - Sternal blood flow during mobilization of the internal thoracic arteries. 11698949 - Should the supplemental vein graft be anastomosed upstream or downstream of the interna... 18845369 - Risk of hemodialysis graft thrombosis: analysis of monthly flow surveillance. 10395269 - A computer model for the prediction of left epicardial coronary blood flow in normal, s... 15172269 - Digital blood flow after radial artery harvest for coronary artery bypass grafting. 1483119 - Flow visualization analysis in a model of artery-graft anastomosis. 6690839 - Effect of descending thoracic aorta clamping and unclamping on phasic coronary blood flow. 9212929 - An automatic flow controller for a centrifugal blood pump. 12780509 - Prediction of single-pool kt/v based on clinical and hemodialysis variables using multi... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery Volume: 19 ISSN: 1078-5884 ISO Abbreviation: Eur J Vasc Endovasc Surg Publication Date: 2000 Jan |
Date Detail:
|
Created Date: 2000-04-05 Completed Date: 2000-04-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9512728 Medline TA: Eur J Vasc Endovasc Surg Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 12-20 Citation Subset: IM |
Copyright Information:
|
Copyright 2000 Harcourt Publishers Ltd. |
Affiliation:
|
Departments of Plastic and Reconstructive Surgery and Experimental Research, Malmö University Hospital, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Vessel Prosthesis Blood Vessel Prosthesis Implantation* Dextrans / pharmacology* Female Graft Occlusion, Vascular / prevention & control* Hemodilution* Male Polytetrafluoroethylene* Rabbits Regional Blood Flow Saline Solution, Hypertonic / pharmacology* Time Factors Venae Cavae* |
| Chemical | |
Reg. No./Substance:
|
0/Saline Solution, Hypertonic; 9002-84-0/Polytetrafluoroethylene; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Endovascular healing is inadequate for fixation of Dacron stent-grafts in human aortoiliac vessels.
Next Document: Abdominal aortic laparoscopic surgery: retroperitoneal or transperitoneal approach?