Document Detail


Effects of hyperthermic intraoperative peritoneal lavage on intra-abdominal pressure in an experimental model of peritonitis: A randomized, controlled, blinded interventional study.
MedLine Citation:
PMID:  21912008     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Hyperthermic Intraoperative Peritoneal Lavage (HIPL) is useful for bacterial decontamination and prevention of hypothermia during damage-control surgery (DCS). Little is known about the effect of HIPL on intra-abdominal pressure (IAP) alone or in combination with peritonitis. Aim: To determine the effects of HIPL at graded temperatures on IAP in the context of DCS. Materials and Methods: A total of 40 rabbits randomly assigned to aseptic-thermal (AT) and peritonitis-thermal (PT) groups and subgroups underwent HIPL at 40°C, 43°C, 46°C, and 49°C. The AT subgroup assigned 40°C was the control group. HIPL was done with a volume of 100 ml/kg. Hourly IAP measurement by two independent observers who were mutually blinded was done through a peritoneal balloon pouch connected to a manometer for 12 hours. Results: All rabbits in group AT survived for at least 11 hours, while all the rabbits in group PT died between 4 and 8 hours. There was significant IAP rise at 4 hours in all subgroups in comparison with the control (I AT40 ): III AT46 ( P < 0.01), IV AT49 ( P < 0.001), V PT40 ( P < 0.01), VI PT43 ( P < 0.01), VII PT46 ( P < 0.001), and P 49 ( P < 0.001) except II AT43 ( P = 0.85). Multiple linear regression analysis showed a positive correlation: Coefficient of regression {r = 0.85 (AT) and r = 0.89 (PT)} and coefficient of determination {r 2 = 0.73 (AT) and r 2 = 0.80 (PT)}. Conclusion: Our findings suggest that beyond 3°C above the normal body temperature in this species, HIPL acts synergistically with peritonitis to exacerbate intra-abdominal hypertension and is associated with a shortened survival postoperatively due to abdominal compartment syndrome.
Authors:
Robert B Sanda; Aslam A Patta; Omer A Omer; Syed Ashraf; Elrasheed Omar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of African medicine     Volume:  10     ISSN:  0975-5764     ISO Abbreviation:  Ann Afr Med     Publication Date:    2011 Jul-Sep
Date Detail:
Created Date:  2011-09-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231417     Medline TA:  Ann Afr Med     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Affiliation:
Hail General Hospital, Hail 81451, Kingdom of Saudi Arabia, Drumheller Hospital, Drumheller, T0J 0Y1, Alberta, Canada, .
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