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Effects of hyperoxic ventilation on 6-hours survival at the critical haemoglobin concentration aggravated by experimentally induced tachycardia in anaesthetized pigs.
MedLine Citation:
PMID:  21883958     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  Administration of 100% oxygen (hyperoxic ventilation, HV) has been proven to ameliorate oxygen transport, tissue oxygenation, and survival in different models of extreme normovolemic and hypovolemic anaemia. However, up to date it is unknown, whether hyperoxic ventilation is also able to improve outcome of extreme anaemia if myocardial oxygen consumption is contemporaneously increased by tachycardia. Therefore we investigated the influence of hyperoxic ventilation on the 6-hours survival rate during extreme anaemia and aggravated by experimentally induced tachycardia in a prospective, randomized study in a pig model of critical anaemia. Methods:  After government approval 14 anesthetized pigs mechanically ventilated on room air were haemodiluted by replacing a certain amount of whole blood with hydroxethylstarch 6% (200.000/0.5) until their individual critical haemoglobin concentration (Hb(crit) ) was achieved. At Hb(crit) tachycardia (180 bpm) was induced in all animals by atrial pacing. Thereafter animals were observed for the next 6-hours either at room air (FiO(2) 0.21; group NOX) or during hyperoxic ventilation (FiO(2) 1.0; group HOX) without further intervention. As primary outcome parameter of this study the 6-hours survival rate was selected. Results:  Hyperoxic ventilation increased the 6-hours survival rate from 14% to 100%. In contrast to the NOX group macrohaemodynamics and oxygen transport improved in the HOX group during the observation period without apparent adverse effects of hyperoxic ventilation. Conclusions:  Hyperoxic ventilation can be considered a safe and effective measure for the optimization of oxygen supply during extreme anaemia and despite concomitant tachycardia within 6-hours. Whether hyperoxic ventilation can also be recommended beyond this period warrants further studies.
Authors:
Harry Kertscho; Patrick Lauscher; Lisa Raab; Kai Zacharowski; Jens Meier
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-23
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  -     ISSN:  1748-1716     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Scandinavian Physiological Society.
Affiliation:
Resident Consultant Professor and Director, Clinic of Anesthesiology, Intensive Care Medicine, and Pain Therapy J. W. Goethe-University Hospital Frankfurt, Germany Resident, Clinic of Anesthesiology, Surgical Intensive Care Medicine and Pain Management, Krankenhaus Nordwest, Frankfurt, Germany.
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