Document Detail


Effects of hyperhomocysteinemia on arterial pressure and nitric oxide production in pregnant rats.
MedLine Citation:
PMID:  19629051     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: An elevated plasma level of homocysteine (hyperhomocysteinemia) is thought to be an important risk factor for a variety of cardiovascular diseases including preeclampsia. Although clinical studies have reported a two- to threefold elevation in plasma levels of homocysteine in women who developed preeclampsia, the importance of hyperhomocysteinemia in causing endothelial dysfunction and increases in arterial pressure during pregnancy is unknown.
METHODS: Therefore, the purpose of this study was to determine the effects of a two- to threefold elevation in plasma homocysteine levels on arterial pressure, chronic pressure-natriuresis relationship, and endothelial factors during pregnancy in the rat. Homocysteine treatment for 4 weeks increased plasma homocysteine levels in pregnant rats from 7.1 +/- 1.9 to 16.7 +/- 2.3 micromol/l.
RESULTS: Homocysteine treatment decreased urinary nitrate/nitrite levels from 53 +/- 7 vs. 39 +/- 5 (micromol/24 h/kg body weight) in pregnant rats whereas having no effect on urinary excretion of endothelin. Homocysteine treatment had no effect on mean arterial pressure (MAP) in pregnant rats (104 +/- 2 vs. 107 +/- 3 mm Hg) nor on the chronic pressure-natriuresis relationship.
CONCLUSIONS: These results suggest that although hyperhomocysteinemia decreases nitric oxide (NO) production in pregnant rats, hyperhomocysteinemia does not affect MAP, the chronic pressure-natriuresis relationship, or urinary excretion of endothelin in pregnant rats. Moreover, the reported two- to threefold elevation in plasma level of homocysteine in women with preeclampsia is unlikely to contribute to the hypertension of preeclampsia.
Authors:
Derrick L Chandler; Maria T Llinas; Jane F Reckelhoff; Babbette LaMarca; Joshua Speed; Joey P Granger
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-07-23
Journal Detail:
Title:  American journal of hypertension     Volume:  22     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-24     Completed Date:  2010-01-14     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1115-9     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Female
Homocysteine / blood
Hyperhomocysteinemia / complications,  metabolism*,  physiopathology*
Nitric Oxide / metabolism*
Pre-Eclampsia / etiology
Pregnancy
Pregnancy Complications, Cardiovascular / metabolism*,  physiopathology*
Rats
Grant Support
ID/Acronym/Agency:
F32 HL078147/HL/NHLBI NIH HHS; F32 HL078147-03/HL/NHLBI NIH HHS; HL-07635/HL/NHLBI NIH HHS; HL-51971/HL/NHLBI NIH HHS; P01 HL051971-165259/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; 454-28-4/Homocysteine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Association of blood pressure and cardiovascular mortality in India: Mumbai cohort study.
Next Document:  Neural mechanisms associated with food motivation in obese and healthy weight adults.