| Effects of hyperhomocysteinemia on arterial pressure and nitric oxide production in pregnant rats. | |
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MedLine Citation:
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PMID: 19629051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: An elevated plasma level of homocysteine (hyperhomocysteinemia) is thought to be an important risk factor for a variety of cardiovascular diseases including preeclampsia. Although clinical studies have reported a two- to threefold elevation in plasma levels of homocysteine in women who developed preeclampsia, the importance of hyperhomocysteinemia in causing endothelial dysfunction and increases in arterial pressure during pregnancy is unknown. METHODS: Therefore, the purpose of this study was to determine the effects of a two- to threefold elevation in plasma homocysteine levels on arterial pressure, chronic pressure-natriuresis relationship, and endothelial factors during pregnancy in the rat. Homocysteine treatment for 4 weeks increased plasma homocysteine levels in pregnant rats from 7.1 +/- 1.9 to 16.7 +/- 2.3 micromol/l. RESULTS: Homocysteine treatment decreased urinary nitrate/nitrite levels from 53 +/- 7 vs. 39 +/- 5 (micromol/24 h/kg body weight) in pregnant rats whereas having no effect on urinary excretion of endothelin. Homocysteine treatment had no effect on mean arterial pressure (MAP) in pregnant rats (104 +/- 2 vs. 107 +/- 3 mm Hg) nor on the chronic pressure-natriuresis relationship. CONCLUSIONS: These results suggest that although hyperhomocysteinemia decreases nitric oxide (NO) production in pregnant rats, hyperhomocysteinemia does not affect MAP, the chronic pressure-natriuresis relationship, or urinary excretion of endothelin in pregnant rats. Moreover, the reported two- to threefold elevation in plasma level of homocysteine in women with preeclampsia is unlikely to contribute to the hypertension of preeclampsia. |
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Authors:
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Derrick L Chandler; Maria T Llinas; Jane F Reckelhoff; Babbette LaMarca; Joshua Speed; Joey P Granger |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-07-23 |
Journal Detail:
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Title: American journal of hypertension Volume: 22 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-24 Completed Date: 2010-01-14 Revised Date: 2013-06-02 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 1115-9 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure* Female Homocysteine / blood Hyperhomocysteinemia / complications, metabolism*, physiopathology* Nitric Oxide / metabolism* Pre-Eclampsia / etiology Pregnancy Pregnancy Complications, Cardiovascular / metabolism*, physiopathology* Rats |
| Grant Support | |
ID/Acronym/Agency:
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F32 HL078147/HL/NHLBI NIH HHS; F32 HL078147-03/HL/NHLBI NIH HHS; HL-07635/HL/NHLBI NIH HHS; HL-51971/HL/NHLBI NIH HHS; P01 HL051971-165259/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 454-28-4/Homocysteine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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