| Effects of hypercapnia, hypocapnia, and hyperoxemia on brain morphometrics determined by use of T1-weighted magnetic resonance imaging in isoflurane-anesthetized dogs. | |
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MedLine Citation:
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PMID: 20807139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effects of various combinations of PaCO2 and PaO2 values on brain morphometrics. ANIMALS: 6 healthy adult dogs. PROCEDURES: A modified Latin square design for randomization was used. Dogs were anesthetized with propofol (6 to 8 mg/kg, IV), and anesthesia was maintained with isoflurane (1.7%) and atracurium (0.2 mg/kg, IV, q 30 min). Three targeted values of PaCO2 (20, 40, and 80 mm Hg) and 2 values of PaO2 (100 and 500 mm Hg) were achieved in each dog, yielding 6 combinations during a single magnetic resonance (MR) imaging session. When the endpoints were reached, dogs were given at least 5 minutes for physiologic variables to stabilize before T1-weighted MR images were obtained. Total brain volume (TBV) and lateral ventricular volume (LVV) were calculated from manually drawn contours of areas of interest by use of a software program, with each dog serving as its own control animal. Three blinded investigators subjectively evaluated the lateral ventricular size (LVS) and the cerebral sulci width (CSW). Brain morphometric values were compared among the target blood gas states. RESULTS: No significant differences in TBV were found among target states. The LVV was significantly greater during hypocapnia, compared with hypercapnia at the same PaO2 value. With regard to the subjective evaluations, there were no significant differences among evaluators or among combinations of PaO2 and PaCO2 values. CONCLUSIONS AND CLINICAL RELEVANCE: The changes observed in LVV during hypocapnia and hypercapnia may serve as a potential confounding factor when neuromorphometric evaluations are performed in anesthetized dogs. |
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Authors:
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Eva Rioja; Wayne N McDonell; Carolyn L Kerr; Howard Dobson; Norman B Konyer; Roberto Poma; Heather J Chalmers; Michael D Noseworthy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 71 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: United States |
Other Details:
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Languages: eng Pagination: 1011-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada. eva.riojagarcia@up.ac.za |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia
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methods,
veterinary Animals Blood Flow Velocity Blood Volume Brain / anatomy & histology, physiology*, physiopathology Carbon Dioxide / blood Cerebrovascular Circulation / physiology Dogs Hypercapnia / physiopathology, veterinary* Hyperoxia / physiopathology, veterinary* Hypocapnia / physiopathology, veterinary* Magnetic Resonance Imaging Oximetry / methods, veterinary Oxygen / blood Propofol |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 2078-54-8/Propofol; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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