Document Detail

Effects of hyperbaric oxygenation on blood pressure levels of spontaneously hypertensive rats.
MedLine Citation:
PMID:  20504127     Owner:  NLM     Status:  MEDLINE    
Five-week-old normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were subjected to hyperbaric oxygenation with an enhanced atmospheric pressure (950 mmHg) and an increased oxygen concentration (36%) for 6 h per day. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were monitored for 8 weeks of hyperbaric oxygenation period. After 8 weeks of hyperbaric oxygenation, the derivatives of reactive oxygen metabolites (dROMs) and biological antioxidant potentials (BAPs) were measured. After 5 weeks of hyperbaric oxygenation, the hyperbaric group of WKY exhibited lower SBP than the age-matched normobaric group, while there were no differences in the DBP between the normobaric and hyperbaric groups. After 3 and 7 weeks of hyperbaric oxygenation, the hyperbaric group of SHR exhibited lower SBP and DBP than the age-matched normobaric group. The hyperbaric groups of both WKY and SHR exhibited lower dROMs than the respective normobaric groups. There were no differences in BAPs between the normobaric and hyperbaric groups of WKY. In contrast, the hyperbaric group of SHR exhibited higher BAPs than the normobaric group. We conclude that the hyperbaric oxygenation conditions used in this study effectively repress hypertension.
Fumiko Nagatomo; Hidemi Fujino; Isao Takeda; Akihiko Ishihara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  32     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
Laboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan.
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MeSH Terms
Atmospheric Pressure*
Blood Pressure / physiology*
Hyperbaric Oxygenation*
Hypertension / therapy*
Rats, Inbred SHR
Rats, Inbred WKY
Erratum In:
Clin Exp Hypertens. 2010;32(5):318

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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