| Effects of hyperbaric oxygen on rat embryos. | |
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MedLine Citation:
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PMID: 8373909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to investigate the toxic effects of hyperbaric oxygen (HBO) on rat embryos. Two groups of Fischer pregnant rats were exposed to oxygen at pressures of 324 and 426 kPa for 90 min per day for 5 consecutive days (8-12 days of gestation). The third group was exposed to normobaric oxygen for 12 h on the eighth day of gestation. Two control groups were used; the first was comprised of intact and the second of sham-treated animals. The HBO treatment did not significantly affect maternal weight gain or reduce litter size, nor did it induce any embryonic abnormalities. However, the fetal body weight was reduced and the placental weight increased in the groups exposed to HBO at pressures of 324 and 426 kPa. When female fetuses which had been exposed to oxygen at 324 or 426 kPa were compared to the intact control group, a reduction in wet weights of 9.2 (p < 0.05) and 12.1% (p < 0.01), respectively, was noted. Male fetuses exposed to oxygen at 324 and 426 kPa displayed a reduced body weight of 11.7 (p < 0.01) and 16.6% (p < 0.01), respectively. Placental weight was increased by 18.9 (p < 0.01) and 23.6% (p < 0.01) in the groups exposed to oxygen at 324 and 426 kPa, respectively. These data suggest that HBO, either at 324 or 426 kPa, is not potent at inducing malformations and that the largest embryotoxic effects are upon fetal body weight and placental weight.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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D Sapunar; M Saraga-Babić; M Peruzović; M Marusić |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biology of the neonate Volume: 63 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1993 |
Date Detail:
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Created Date: 1993-10-21 Completed Date: 1993-10-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 360-9 Citation Subset: IM |
Affiliation:
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Department of Histology and Embryology, University of Zagreb, School of Medicine, Republic of Croatia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Congenital Abnormalities / etiology* Embryonic and Fetal Development* Female Hyperbaric Oxygenation / adverse effects* Litter Size Male Maternal-Fetal Exchange Organ Size Placenta* / anatomy & histology, blood supply Pregnancy Rats Rats, Inbred F344 Sex Factors Weight Gain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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