Document Detail

Effects of hyperbaric oxygen on rat embryos.
MedLine Citation:
PMID:  8373909     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to investigate the toxic effects of hyperbaric oxygen (HBO) on rat embryos. Two groups of Fischer pregnant rats were exposed to oxygen at pressures of 324 and 426 kPa for 90 min per day for 5 consecutive days (8-12 days of gestation). The third group was exposed to normobaric oxygen for 12 h on the eighth day of gestation. Two control groups were used; the first was comprised of intact and the second of sham-treated animals. The HBO treatment did not significantly affect maternal weight gain or reduce litter size, nor did it induce any embryonic abnormalities. However, the fetal body weight was reduced and the placental weight increased in the groups exposed to HBO at pressures of 324 and 426 kPa. When female fetuses which had been exposed to oxygen at 324 or 426 kPa were compared to the intact control group, a reduction in wet weights of 9.2 (p < 0.05) and 12.1% (p < 0.01), respectively, was noted. Male fetuses exposed to oxygen at 324 and 426 kPa displayed a reduced body weight of 11.7 (p < 0.01) and 16.6% (p < 0.01), respectively. Placental weight was increased by 18.9 (p < 0.01) and 23.6% (p < 0.01) in the groups exposed to oxygen at 324 and 426 kPa, respectively. These data suggest that HBO, either at 324 or 426 kPa, is not potent at inducing malformations and that the largest embryotoxic effects are upon fetal body weight and placental weight.(ABSTRACT TRUNCATED AT 250 WORDS)
D Sapunar; M Saraga-Babić; M Peruzović; M Marusić
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  63     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1993  
Date Detail:
Created Date:  1993-10-21     Completed Date:  1993-10-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  360-9     Citation Subset:  IM    
Department of Histology and Embryology, University of Zagreb, School of Medicine, Republic of Croatia.
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MeSH Terms
Body Weight
Congenital Abnormalities / etiology*
Embryonic and Fetal Development*
Hyperbaric Oxygenation / adverse effects*
Litter Size
Maternal-Fetal Exchange
Organ Size
Placenta* / anatomy & histology,  blood supply
Rats, Inbred F344
Sex Factors
Weight Gain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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