Document Detail

Effects of hydroxyethyl starch on cardiac output in hypotensive neonates: a comparison with isotonic saline and 5% albumin.
MedLine Citation:
PMID:  16825135     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the effects of hydroxyethyl starch (6% HES 200/0.5) on cardiac output in hypotensive neonates with low cardiac output and absence of myocardial dysfunction. METHODS: In a prospective randomized blinded trial, 21 hypotensive neonates (mean gestational age of 29+/-3 wk) were randomly allocated to receive infusions of either 5% albumin (albumin group), isotonic saline (saline group) or hydroxyethyl starch (HES group). Infants had to show low cardiac output and an absence of myocardial dysfunction for inclusion in the study. Cardiac output was assessed by Doppler-derived mean aortic flow velocity. RESULTS: Ten minutes after infusion, 67% of all infants had more than a 10% increase in cardiac output. Increases in mean aortic flow velocity (m/s; median and range) were 0.05 (-0.02, +0.07), 0.03 (-0.03, +0.12) and 0.03 (-0.04, +0.11) for the albumin, saline and HES groups, respectively (p = 0.79). The percentage of blood pressure normalization (95% confidence interval) was 86% (60-100) in the albumin group, 57% (20-94) in the saline group and 71% (37-100) in the HES group (p = 0.50). CONCLUSION: This study did not provide evidence that hydroxyethyl starch is more efficient than isotonic saline or albumin.
Jean Michel Liet; Alice Kuster; Sophie Denizot; Gaelle Caillaux-Varin; Christele Gras-Leguen; Jean-Christophe Rozé
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  95     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-07-07     Completed Date:  2006-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  555-60     Citation Subset:  IM    
Paediatric and Neonatal Intensive Care Unit, University Hospital of Nantes, France.
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MeSH Terms
Albumins / pharmacology
Cardiac Output / drug effects*
Double-Blind Method
Hetastarch / pharmacology*
Hypotension / physiopathology*
Infant, Newborn
Isotonic Solutions
Plasma Substitutes / pharmacology*
Respiration, Artificial
Sodium Chloride / pharmacology
Reg. No./Substance:
0/Albumins; 0/Isotonic Solutions; 0/Plasma Substitutes; 7647-14-5/Sodium Chloride; 9005-27-0/Hetastarch

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