Document Detail

Effects of hydrophilic and lipophilic beta-sitosterol derivatives on cholesterol absorption and plasma cholesterol levels in rats.
MedLine Citation:
PMID:  18616266     Owner:  NLM     Status:  MEDLINE    
The effects of two phytosterol derivatives of beta-sitosterol, a lipophilic derivative (LPSS) and a hydrophilic derivative (HPSS), on cholesterol uptake and blood lipoprotein levels in rats were compared with those of beta-sitosterol. LPSS and HPSS have solubilities of up to 0.05 g/mL in edible oil and 0.15 g/mL in water at 25 degrees C, respectively. The intragastric administration of either 30 or 50 mg of phytosterols with 10 mg of [4- (14)C]-cholesterol per kg of body weight once a day for 3 consecutive days reduced cholesterol uptake by approximately 30% compared to controls that received cholesterol alone. Feeding a cholesterol-enriched diet containing 1% or 3% beta-sitosterol, LPSS, or HPSS for 2 and 4 weeks resulted in lowered levels of total blood cholesterol and reduced the atherogenic index in all groups. These results indicate that LPSS and HPSS have comparable effects to beta-sitosterol in lowering blood cholesterol levels but they differ from beta-sitosterol in having a solubility advantage.
Dae-Won Chung; Won-Dai Kim; Seung Kwon Noh; Mi-Sook Dong
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Publication Detail:
Type:  Journal Article     Date:  2008-07-11
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  56     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6665-70     Citation Subset:  IM    
Department of Polymer Engineering, University of Suwon, Gyeonggi-do 445-743, Korea.
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MeSH Terms
Cholesterol / blood*
Cholesterol, Dietary / administration & dosage,  pharmacokinetics*
Intestinal Absorption
Rats, Sprague-Dawley
Sitosterols / chemistry,  pharmacology*
Specific Pathogen-Free Organisms
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Sitosterols; 57-88-5/Cholesterol; 5779-62-4/sitosterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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