Document Detail


Effects of hydration and dehydration on blood rheology in sickle cell trait carriers during exercise.
MedLine Citation:
PMID:  20581085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compared the hemorheological responses of a group of sickle cell trait (SCT) carriers with those of a control (Cont) group in response to 40 min of submaximal exercise (exercise intensity, 55% aerobic peak power) performed in two conditions: one with water offered ad libitum, i.e., the hydration (Hyd) condition, and one without water, i.e., the dehydration (Dehyd) condition. Blood and plasma viscosities, as well as red blood cell rigidity, were determined at rest, at the end of exercise, and at 2 h recovery with a cone plate viscometer at high shear rate and 37 degrees C. The SCT and Cont groups lost 1 +/- 0.7 and 1.6 +/- 0.6 kg of body weight, respectively, in the Dehyd condition, indicating a significant effect of water deprivation compared with the Hyd condition, in which body weight remained unchanged. Plasma viscosity increased with exercise and returned to baseline during recovery independently of the group and condition. As previously demonstrated, resting blood viscosity was greater in the SCT carriers than in the Cont group. Blood viscosity increased by the end of exercise and returned to baseline at 2 h recovery in the Cont group in both conditions. The blood viscosity of SCT carriers did not change in response to exercise in the Dehyd condition and remained elevated at 2 h recovery. This extended hyperviscosity, in association with other biological changes induced by exercise, could be considered as a risk factor for exercise-related events in SCT carriers, similar to vasoocclusive crises, notably during the recovery. In contrast, the Hyd condition normalized the hyperviscosity and red blood cell rigidity of the SCT carriers, with blood viscosity values reaching the same lower values as those found in the Cont group during the recovery. Adequate hydration of SCT carriers should be strongly promoted to reduce the clinical risk associated with potential hyperviscosity complications.
Authors:
Julien Tripette; Gylna Loko; Abdoulaye Samb; Bertin Doubi Gogh; Estelle Sewade; Djibril Seck; Olivier Hue; Marc Romana; Saliou Diop; Mor Diaw; Karine Brudey; Pascal Bogui; Fallou Cissé; Marie-Dominique Hardy-Dessources; Philippe Connes
Related Documents :
12839195 - Resilience of epilithic algal assemblages in atmospherically and experimentally acidifi...
2722325 - Complement and immunoglobulin levels in athletes and sedentary controls.
7264995 - The kinetics of post-vibration tension recovery of the isolated rat portal vein.
12740735 - Effects of active recovery under a decreasing work load following intense muscular exer...
15689345 - Cardiovascular pre-participation screening of young competitive athletes for prevention...
7778465 - Phosphate metabolism of prior eccentrically loaded vastus medialis muscle during exerci...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-25
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  299     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H908-14     Citation Subset:  IM    
Affiliation:
Laboratoire Acclimation au Climat Tropical, Exercice et Santé (EA 3596), Département de Physiologie, Université des Antilles et de Guyane, Pointe-à-Pitre, Guadeloupe.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Viscosity / physiology
Dehydration / blood*,  physiopathology
Exercise / physiology*
Female
Hemorheology / physiology*
Humans
Male
Sickle Cell Trait / blood*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of...
Next Document:  Hypoxic relaxation of penile arteries: involvement of endothelial nitric oxide and modulation by rea...