Document Detail

Effects of a human milk-derived human milk fortifier on the antibacterial actions of human milk.
MedLine Citation:
PMID:  18081457     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare the effects of a human breastmilk-derived fortifier on the antibacterial activity of milk obtained from lactating mothers delivering prematurely with the effects of a powdered fortifier on the same milk. STUDY DESIGN: Human milk samples were obtained after the first week of postnatal life from 10 lactating mothers, who had delivered prematurely. A bovine milk-based powdered fortifier and a human breastmilk-based frozen fortifier were evaluated. All mothers were healthy and they were not on any medications, although they were taking prenatal vitamins during lactation. The effects of each fortifier on the antimicrobial activity of milk toward Enterobacter sakazaki (ES), Escherichia coli, Clostridium difficile (CD), and Shigella soneii (SS) were evaluated by both the filter paper method and the growth inhibition method. RESULTS: Human milk inhibited the growth of all of the test organisms. This antibacterial activity was almost totally inhibited by the addition of the bovine protein-based human milk fortifier, while it remained unaffected by the addition of the human breastmilk-based fortifier. CONCLUSIONS: Breastmilk from women who have delivered preterm has antibacterial activity that can be affected by the addition of bovine-based fortifier, but not by the addition of a human breastmilk-based fortifier.
Gary M Chan; Martin L Lee; David J Rechtman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine     Volume:  2     ISSN:  1556-8342     ISO Abbreviation:  -     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101260777     Medline TA:  Breastfeed Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  205-8     Citation Subset:  IM    
Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
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MeSH Terms
Clostridium difficile / growth & development
Enterobacter sakazakii / growth & development
Escherichia coli / drug effects
Food, Fortified*
Infant Formula / chemistry*
Infant, Newborn
Infant, Premature*
Milk / immunology
Milk Proteins / pharmacology*
Milk, Human / immunology*
Shigella sonnei / growth & development
Reg. No./Substance:
0/Milk Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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