Document Detail


Effects of human chorionic gonadotropin on luteal blood flow and progesterone secretion in cows and in vitro-microdialyzed corpora lutea.
MedLine Citation:
PMID:  19515407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To check human chorionic gonadotropin (hCG) effects on luteal blood flow (LBF) and progesterone (P(4)) synthesis, six cows received either 3000 IU hCG or saline (NaCl) on Day 7 (Day 1=ovulation) during two estrous cycles. Plasma P(4) and LBF were measured before (0h) and up to 48h after treatment. Luteal blood flow increased by 51% (P<0.05) at 1h after hCG administration and returned to baseline levels thereafter. Plasma P(4) levels were increased from pretreatment levels by 30% at 1h (P=0.05) and 81% at 48h (P=0.02) after hCG treatment. In contrast, NaCl did not cause changes in LBF and P(4) (P>0.05). Additionally, central and peripheral parts of 14 abattoir-derived corpora lutea of the mid-luteal phase (Day 8 to 12) were perfused with Ringer solution in an in vitro microdialysis system, supplemented with 50 or 150 IU/mL hCG for 1h. Application of 50 IU/mL hCG showed no influence on P(4) response (P>0.05) in both central and peripheral parts, whereas 150 IU/mL hCG resulted in an increase of P(4) synthesis (P=0.002) in the central parts only. In vivo, hCG provoked an immediate and long-term rise in P(4) but only a temporary elevation of LBF. Luteal blood flow itself does not seem to be the exclusive cause for an increase in P(4), because the in vitro data clearly showed direct effects of hCG on P(4) secretion. Interestingly, different P(4) secretion patterns could be found between central and peripheral parts of the corpus luteum in both control and hCG perfused corpora lutea.
Authors:
N Beindorff; A Honnens; Y Penno; V Paul; H Bollwein
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Publication Detail:
Type:  In Vitro; Journal Article     Date:  2009-06-09
Journal Detail:
Title:  Theriogenology     Volume:  72     ISSN:  1879-3231     ISO Abbreviation:  Theriogenology     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421510     Medline TA:  Theriogenology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-34     Citation Subset:  IM    
Affiliation:
Clinic for Cattle, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany. n_beindorff@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Chorionic Gonadotropin / pharmacology*
Corpus Luteum / blood supply*,  drug effects*,  secretion
Estrous Cycle / blood,  drug effects*
Female
Microdialysis
Progesterone / secretion*
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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