| Effects of horsefly (Tabanidae) salivary gland extracts on isolated perfused rat heart. | |
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MedLine Citation:
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PMID: 18092977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The speed with which horseflies (Diptera: Tabanidae) obtain a bloodmeal suggests they have potent vasodilators. We used isolated perfused rat heart to examine the vasoactivity of salivary gland extracts (SGEs) of three horsefly species, Hybomitra bimaculata Macquart, Tabanus bromius Linnaeus and Tabanus glaucopis Meigen. Administration of horsefly SGEs to the heart produced biphasic coronary responses: a decrease and subsequent increase in coronary flow (CF), characterized by initial vasoconstriction followed by prolonged vasodilation of coronary vessels. However, although SGEs of H. bimaculata induced a significant decrease in left ventricular pressure (LVP), the effect on changes in CF was not significant except at the highest dose tested. The ability to reduce LVP without significantly lowering CF, or affecting heart rate and rhythm, represents a unique set of properties that have considerable therapeutic potential if they can be reproduced by a single molecule. |
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Authors:
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P Rajská; V Knezl; M Kazimírová; P Takác; L Roller; L Vidlicka; F Ciampor; M Labuda; W Weston-Davies; P A Nuttall |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical and veterinary entomology Volume: 21 ISSN: 0269-283X ISO Abbreviation: Med. Vet. Entomol. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-20 Completed Date: 2008-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708682 Medline TA: Med Vet Entomol Country: England |
Other Details:
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Languages: eng Pagination: 384-9 Citation Subset: IM |
Affiliation:
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Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation Coronary Vessels / drug effects Diptera / chemistry*, classification, physiology* Dose-Response Relationship, Drug Feeding Behavior / physiology Heart Rate / drug effects Male Rats Rats, Wistar Salivary Glands / chemistry* Species Specificity Tissue Extracts / pharmacology* Vasodilation / drug effects Vasodilator Agents / pharmacology* Ventricular Pressure / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Tissue Extracts; 0/Vasodilator Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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