| Effects of hormone replacement therapy on platelet membrane fatty acid composition. | |
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MedLine Citation:
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PMID: 8699134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oestrogen replacement therapy has been shown to protect postmenopausal women from ischaemic heart disease, strokes and hypertension. The mechanism of protection conferred by oestrogen, although partly attributable to changes in serum lipoproteins, is not fully understood. The present study was undertaken to assess the effect of hormone replacement therapy on the composition of platelet membrane fatty acids in postmenopausal women. These were analysed by gas-liquid chromatography before and six weeks after continuous conjugated equine oestrogen therapy (0.625 mg daily) combined with cyclical therapy with 75 micrograms L-norgestrel from day 17 to 28 of a 28-day cycle. Each subject acted as her own control. The principal findings of the study were that, following treatment, there was a 16.2% reduction in platelet membrane polyunsaturated fatty acids (P < 0.001), an increase of 9.1 and 7.1% in saturated fatty acids and monounsaturated fatty acids respectively (P < 0.001) and a 17.8% reduction in arachidonic acid (P < 0.003). There was no correlation between changes in membrane fatty acids and serum lipoproteins. This suggests that the changes in membrane composition noted in this study may be a primary effect of hormone replacement therapy, especially oestrogen. |
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Authors:
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L R Ranganath; J A Christofides; J W Wright; V Marks |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of endocrinology Volume: 148 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-09-05 Completed Date: 1996-09-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 207-12 Citation Subset: IM |
Affiliation:
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Department of Clinical Biochemistry, West Park Hospital, Epsom, Surrey, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arachidonic Acid / metabolism Blood Platelets / drug effects*, metabolism Estrogen Replacement Therapy* Estrogens / pharmacology* Fatty Acids / metabolism* Fatty Acids, Monounsaturated / metabolism Fatty Acids, Unsaturated / metabolism Female Humans Lipoproteins / blood Membrane Lipids / metabolism* Middle Aged Norgestrel / pharmacology* Postmenopause / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Unsaturated; 0/Lipoproteins; 0/Membrane Lipids; 506-32-1/Arachidonic Acid; 6533-00-2/Norgestrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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