| Effects of the histone deacetylase inhibitor ITF2357 in autoinflammatory syndromes. | |
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MedLine Citation:
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PMID: 21274502 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: We explored the effects of the oral histone deacetylase (HDAC) inhibitor ITF2357 in patients with autoinflammatory syndromes. METHODS: In this prospective open-label pilot study 8 patients were enrolled; One patient with Tumour Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS), 3 patients with hyper-IgD and periodic fever syndrome (HIDS) and 4 patients with Schnitzler syndrome were closely followed during 90 days of ITF2357 treatment. RESULTS: Three patients with Schnitzler syndrome and 1 TRAPS patient experienced a partial remission. In 4 patients there was no effect. In HIDS patients there was a tendency towards a higher attack frequency and increasing attack severity. In 2 patients (1 TRAPS and 1 HIDS), we observed a decrease of acute phase response without signs of clinical improvement. One patient with Schnitzler syndrome showed a partial response despite an ongoing acute phase response. CONCLUSION: ITF2357 monotherapy was able to induce partial response only in patients with Schnitzler syndrome and no response in patients with HIDS. |
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Authors:
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Evelien J Bodar; Anna Simon; Jos W M Van Der Meer |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-25 |
Journal Detail:
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Title: Molecular medicine (Cambridge, Mass.) Volume: - ISSN: 1528-3658 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9501023 Medline TA: Mol Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of General Internal Medicine and Nijmegen Institute for Infection, Inflammation, and Immunity (N4i), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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