| Effects of histamine and cholinergic systems on memory retention of passive avoidance learning in rats. | |
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MedLine Citation:
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PMID: 12650837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, the effects of the histamine and cholinergic systems on memory retention in adult male rats were investigated. Post-training intracerebroventricular injections were carried out in all the experiments. Cholinoceptor agonist, acetylcholine (1-10 microg/rat) or nicotine (1-10 microg/rat), increased, while a cholinoceptor antagonist, scopolamine (5-20 microg/rat), decreased memory retention. The response to acetylcholine was attenuated by scopolamine. Administration of histamine (5-20 microg/rat) reduced, but the histamine H(1) receptor antagonist, pyrilamine (10-50 microg/rat), and the histamine H(2) receptor antagonist, cimetidine (1-50 microg/rat), increased memory retention in rats. The histamine receptor antagonists attenuated the response to histamine. Histamine reduced the acetylcholine- or nicotine-induced enhancement. The histamine receptor antagonists enhanced the nicotine- or acetylcholine-induced response. Histamine potentiated the inhibitory effect induced by scopolamine. It is concluded that histaminergic and cholinergic systems have opposing effects on memory retention. Also, the histaminergic system elicits an interaction with the cholinergic system in memory retention. |
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Authors:
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Maryam Eidi; Mohammad-Reza Zarrindast; Akram Eidi; Shahrbanoo Oryan; Kazem Parivar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 465 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-24 Completed Date: 2003-07-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 91-6 Citation Subset: IM |
Affiliation:
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Department of Biology, Sciences and Research Campus, Azad University, Tehran, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Avoidance Learning / drug effects, physiology* Cimetidine / pharmacology Dose-Response Relationship, Drug Histamine H1 Antagonists / pharmacology Histamine H2 Antagonists / pharmacology Male Memory / drug effects, physiology* Muscarinic Antagonists / pharmacology Nicotine / pharmacology Pyrilamine / pharmacology Rats Rats, Wistar Reaction Time Receptors, Cholinergic / physiology* Receptors, Histamine / physiology* Retention (Psychology) / drug effects Scopolamine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Histamine H1 Antagonists; 0/Histamine H2 Antagonists; 0/Muscarinic Antagonists; 0/Receptors, Cholinergic; 0/Receptors, Histamine; 51-34-3/Scopolamine; 51-84-3/Acetylcholine; 51481-61-9/Cimetidine; 54-11-5/Nicotine; 91-84-9/Pyrilamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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