| Effects of histamine H1-receptor blockade on respiratory and cardiac manifestation of systemic anaphylaxis. | |
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MedLine Citation:
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PMID: 1683106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vivo anaphylaxis is associated with respiratory distress and cardiovascular failure. The present investigation was designed to further characterize respiratory and cardiac anaphylactic events. In guinea pigs, sensitization was produced by subcutaneous application of ovalbumin together with Freund's adjuvant. Fourteen days after sensitization, the effects of an intravenous infusion of ovalbumin were tested in the anesthetized artificially ventilated guinea pigs. The renewed application of the antigen induced an initial increase of left ventricular pressure which was followed by a rapid decrease 5 min after antigenic challenge. Enddiastolic left ventricular pressure increased within 3 min, thus indicating left ventricular pump failure. In the same time range, ECG recordings uniformly showed signs of acute myocardial ischemia. In addition, heart rate steadily decreased. All animals died within 15 min. Simultaneously with cardiac anaphylactic malfunction, severe arterial hypoxia and carbon dioxide retention occurred, revealing respiratory distress. Histamine is known as a potent bronchoconstrictor via histamine H1-receptor stimulation. Administration of H1-receptor antagonists to improve respiration may therefore provide further information on the contribution of pulmonary malfunction to anaphylactic cardiovascular shock. Therefore, additional experiments were performed with sensitized guinea pigs pretreated with the histamine H1-receptor blocker mepyramine. In these experiments the antigenic challenge induced a dissociation of cardiac and respiratory manifestation of anaphylaxis. Despite inhibition of hypoxia and carbon dioxide retention, left ventricular pump failure and occurrence of myocardial ischemia were delayed but not suppressed. It is concluded that histamine is an important mediator of anaphylactic respiratory distress. However, vasoactive anaphylactic mediators other than histamine are primarily involved in anaphylactic cardiac malfunction occurring during the later phase of systemic anaphylaxis. |
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Authors:
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S B Felix; G Baumann; T Hashemi; M Niemczyk; G Ochsenfeld; Z Ahmad; S Shirani; H Blömer |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Agents and actions Volume: 33 ISSN: 0065-4299 ISO Abbreviation: Agents Actions Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-12-23 Completed Date: 1991-12-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0213341 Medline TA: Agents Actions Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 349-58 Citation Subset: IM |
Affiliation:
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Department of Medicine I, Technische Universität München, W. Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaphylaxis
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physiopathology* Animals Blood Gas Analysis Electrocardiography Female Guinea Pigs Heart / drug effects, physiopathology* Heart Ventricles / drug effects Histamine / physiology Histamine H1 Antagonists / pharmacology* Male Ovalbumin Pyrilamine / pharmacology Respiration / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Histamine H1 Antagonists; 51-45-6/Histamine; 9006-59-1/Ovalbumin; 91-84-9/Pyrilamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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