Document Detail

Effects of highly purified eicosapentaenoic acid on vascular reactivity to angiotensin II and norepinephrine in pregnant rabbits.
MedLine Citation:
PMID:  9209697     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to determine whether the pressor response to an infusion of angiotensin II during pregnancy would be reduced by the oral administration of highly purified eicosapentaenoic acid ethyl ester (EPA-E). METHODS: We administered EPA-E orally to nine pregnant rabbits (200 mg/kg/day) from day 5 of gestation to day 5 postpartum. Pressor responses to graded doses of intravenously infused angiotensin II and norepinephrine were examined serially during pregnancy and the postpartum period. RESULTS: The EPA-E-treated, as well as the control pregnant rabbits (n = 6), were significantly less responsive to the vasoconstrictor effects of angiotensin II throughout pregnancy than the nonpregnant rabbits (n = 8). The vascular reactivity to infused angiotensin II in EPA-E-treated pregnant rabbits, as compared with that of control pregnant rabbits was unchanged, but reactivity to angiotensin II was lower only on the fifth postpartum day. The pressor responses to infused norepinephrine were unchanged during pregnancy and in the postpartum period, and EPA-E did not alter the response. The litters of four of the nine rabbits were partially or completely macerated. CONCLUSION: EPA-E did not reduce the already blunted pressor responsiveness to angiotensin II during pregnancy in rabbits. The effect of EPA-E in a state of increased pressor responsiveness during pregnancy due to a deficiency of vasodilatory prostaglandins needs to be determined.
T Yoshimura; M Ito; K Matsui; H Okamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artery     Volume:  22     ISSN:  0098-6127     ISO Abbreviation:  Artery     Publication Date:  1997  
Date Detail:
Created Date:  1997-08-21     Completed Date:  1997-08-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7508494     Medline TA:  Artery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  242-50     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Kumamoto University School of Medicine, Japan.
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MeSH Terms
Angiotensin II / pharmacology*
Blood Pressure / drug effects*
Eicosapentaenoic Acid / analogs & derivatives*,  isolation & purification,  pharmacology
Infusions, Intravenous
Norepinephrine / pharmacology*
Pregnancy Outcome
Pregnancy, Animal*
Vasomotor System / drug effects*
Reg. No./Substance:
11128-99-7/Angiotensin II; 1553-41-9/Eicosapentaenoic Acid; 51-41-2/Norepinephrine; 73310-10-8/eicosapentaenoic acid ethyl ester

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