Document Detail

Effects of a highly palatable diet on lipid and glucose parameters, nitric oxide, and ectonucleotidases activity.
MedLine Citation:
PMID:  20962914     Owner:  NLM     Status:  MEDLINE    
Obesity has reached epidemic proportions worldwide and is stimulated by the ready availability of food rich in fat and sugar (highly palatable diet). This type of diet increases the risks of obesity-associated pathologies, such as insulin resistance and cardiovascular disease. Nitric oxide, a potent endogenous vasodilator, is decreased in these pathologies, mostly as a result of insulin resistance. Ectonucleotidases are ecto and soluble enzymes that regulate the availability of the nucleotides ATP, ADP, and AMP and the nucleoside adenosine in the vascular system, thereby affecting vasoconstriction, vasodilatation, and platelet aggregation homeostasis. The aim of this study was to evaluate the effects of a highly palatable diet on serum lipid and glucose parameters, nitric oxide, and ectonucleotidase activity. Forty male Wistar rats were fed 1 of 2 diets for either 45 days or 4 months: standard chow (SC, n = 10) or a highly palatable diet enriched with sucrose (HP, n = 10). Body mass, visceral fat mass, glucose tolerance, cholesterol (total, high-density lipoprotein (HDL) and non-HDL), serum triacylglycerol, liver triacylglycerol, and free glycerol were increased in the HP group after 45 days and after 4 months, whereas insulin levels were not different between the groups at either time. Furthermore, levels of nitric oxide metabolites and ATP, ADP, and AMP hydrolysis were significantly lower in the HP group (p < 0.05) after 4 months. In conclusion, the consumption of the HP diet for 4 months induced overall corporal and metabolic changes, and decreased nitric oxide metabolites and ectonucleotidase activity, thereby promoting an appropriate environment for the development of cardiovascular diseases, without apparent changes in insulin levels.
Carolina Guerini de Souza; Ana Elisa Böhmer; Alexandre Pastoris Müller; Jean Pierre Oses; Giordano Gübert Viola; Daniel Neumann Lesczinski; Débora Guerini de Souza; Luísa Knorr; Júlia Dübois Moreira; Francisco Lhullier; Diogo Onofre Souza; Marcos Luiz Santos Perry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  35     ISSN:  1715-5312     ISO Abbreviation:  Appl Physiol Nutr Metab     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-21     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  591-7     Citation Subset:  IM    
Department of Biochemistry, Federal University of Rio Grande do Sul - UFRGS, Rua Ramiro Barcelos, 2600 anexo, CEP 90035003, Porto Alegre, RS, Brazil.
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MeSH Terms
Adenosine Diphosphate / metabolism
Adenosine Monophosphate / metabolism
Adenosine Triphosphatases / metabolism*
Adenosine Triphosphate / metabolism
Animal Feed*
Blood Glucose / metabolism*
Dietary Fats / pharmacology
Dietary Sucrose / pharmacology
Enzyme Activation / physiology
Glucose Intolerance / metabolism
Glycerol / metabolism
Insulin / blood
Lipids / blood*
Nitric Oxide / metabolism*
Obesity / metabolism*
Rats, Wistar
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Fats; 0/Dietary Sucrose; 0/Lipids; 10102-43-9/Nitric Oxide; 11061-68-0/Insulin; 56-65-5/Adenosine Triphosphate; 56-81-5/Glycerol; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/ectoATPase

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