Document Detail

Effects of the high growth (hg) mutation on reproduction in high growth (HG) female mice.
MedLine Citation:
PMID:  10969883     Owner:  NLM     Status:  MEDLINE    
Reproductive performance was characterized in females of a line of mice homozygous for a recessive mutation with a major effect on growth, the high growth (hg) mutation. Specifically, the age at onset of puberty, length of the estrous cycle, ovulation rate, and gestation length in high growth (HG) mice were determined and compared with control mice. HG females reached puberty at an age similar to control animals, exhibited normal ovulation rates and estrous cycle length, but had a shorter length of estrus. Number of fetuses at Day 17 of gestation was greater and gestation length was longer in HG females. The HG females exhibited a variety of reproductive disorders, including increased incidence of repeated detection of mating plugs without intervening pregnancy ("replug"), increased incidence of repeated detection of mating plugs within an interval of 1-8 days without intervening pregnancy ("recycle"), increased interval between pairing with a male and detection of the first mating plug, increased interval between mating and conception, increased postnatal mortality, decreased litter size, and increased incidence of vaginal septum.
S L Cargill; J F Medrano; T R Famula; G B Anderson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Growth, development, and aging : GDA     Volume:  64     ISSN:  1041-1232     ISO Abbreviation:  Growth Dev Aging     Publication Date:    2000 Spring-Summer
Date Detail:
Created Date:  2000-12-11     Completed Date:  2001-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809704     Medline TA:  Growth Dev Aging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-31     Citation Subset:  IM    
Department of Animal Science, University of California, Davis 95616, USA.
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MeSH Terms
Mice, Inbred C57BL
Mice, Mutant Strains / physiology*
Ovulation / physiology
Reproduction / physiology*
Sexual Behavior, Animal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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