| Effects of high fruit-vegetable and/or low-fat intervention on breast nipple aspirate fluid micronutrient levels. | |
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MedLine Citation:
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PMID: 17627004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A change in diet is known to affect micronutrient levels in blood but to what extent diet can affect micronutrient levels in the breast is not yet well established. METHODS: Healthy, premenopausal women with a family history of breast cancer were randomized across four diet arms for 1 year in a 2 x 2 factorial design study: control, low-fat, high fruit-vegetable, and combination low-fat/high fruit-vegetable diets. Subjects were asked to collect breast nipple aspirate fluid (NAF) at 0, 6, and 12 months, and levels of micronutrients were measured in the fluid. RESULTS: A total of 122 women were enrolled, 97 were retained for 12 months, and sufficient NAF for analysis was available from 59 women at baseline, 49 at 6 months, and 50 at 12 months. Repeated measures mixed-model ANOVA was used to model the data using cholesterol levels and lactation duration as covariates, where appropriate. The high fruit-vegetable intervention, regardless of fat intake, significantly increased total carotenoid levels in NAF. In the low-fat arm, levels of total carotenoids decreased over time relative to control. Levels of total tocopherols and retinol did not change significantly. Levels of 15-F(2t)-isoprostane, a marker of lipid peroxidation, also did not change significantly over time, although there was a decrease observed in the combination arm. CONCLUSIONS: These results indicate that total carotenoid levels in NAF can be significantly increased in the breast NAF with a high fruit-vegetable diet. A low-fat diet that was achieved with little increase in fruit and vegetable intake, however, decreased NAF carotenoid levels. |
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Authors:
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Zora Djuric; Gang Chen; Jianwei Ren; Raghu Venkatramanamoorthy; Chandice Y Covington; Omer Kucuk; Lance K Heilbrun |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 16 ISSN: 1055-9965 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-13 Completed Date: 2007-08-28 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 1393-9 Citation Subset: IM |
Affiliation:
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Department of Family Medicine, University of Michigan, Room 2150 Cancer and Geriatrics Center, Ann Arbor, MI 48109-0930, USA. zoralong@umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Breast Neoplasms / blood, epidemiology, prevention & control* Carotenoids / metabolism Diet, Fat-Restricted* Female Fruit* Humans Mammary Glands, Human / secretion* Micronutrients / analysis* Middle Aged Nipples / secretion* Tocopherols / metabolism Vegetables* |
| Grant Support | |
ID/Acronym/Agency:
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CA22453/CA/NCI NIH HHS; U01CA77297/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Micronutrients; 1406-66-2/Tocopherols; 36-88-4/Carotenoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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