| Effects of high fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice. | |
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MedLine Citation:
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PMID: 21525235 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Our previous studies reported that caffeine or voluntary exercise decreased skin tumor multiplicity, in part, by decreasing fat levels in the dermis. These data suggest that tissue fat may play an important role in regulating UVB-induced skin tumor development. In the present study, we explored the effects of high fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis. SKH-1 mice were irradiated with 30 mJ/cm(2) of UVB once a day, two times per week for 39 weeks. During UVB treatment, one group of mice was given a high fat fish oil diet (HFFO) rich in omega-3 fatty acids and the other group of mice was given a high fat mixed lipids diet (HFML) rich in omega-6 fatty acids. The results showed that, compared to HFML diet, HFFO treatment (1) increased latency for the development of UVB-induced skin tumors; (2) decreased the formation of papilloma, keratoacanthoma and carcinoma by 64%, 52%, and 46%, respectively; and (3) decreased the size of papilloma, keratoacanthoma and carcinoma by 98%, 80%, and 83%, respectively. Mechanistic studies with antibody array revealed that compared to HFML diet, administration of HFFO to the mice significantly decreased the UVB-induced increases in the levels of TIMP-1, LIX and sTNF R1 as well as other several pro-inflammatory cytokines, and stimulated the UVB-induced apoptosis in the epidermis. Our results indicate that omega-3 fatty acids in HFFO diet have beneficial effects against UVB-induced skin carcinogenesis, and these effects may be associated with an inhibition on UVB-induced inflammatory response. |
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Authors:
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You-Rong Lou; Qing-Yun Peng; Tao Li; Christopher M Medvecky; Yong Lin; Weichung Joe Shih; Allan H Conney; Sue Shapses; George C Wagner; Yao-Ping Lu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-27 |
Journal Detail:
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Title: Carcinogenesis Volume: - ISSN: 1460-2180 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology Ernest Mario School of Pharmacy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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