Document Detail


Effects of a high-fat diet on postabsorptive and postprandial testosterone responses to a fat-rich meal.
MedLine Citation:
PMID:  11699056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postprandial testosterone concentrations have been shown to significantly decrease after a fat-rich meal, which may be due to inhibition of testosterone production by chylomicrons. We examined the effects of a high-fat diet known to reduce postprandial chylomicrons on the testosterone response to a fat-rich meal. Total testosterone (TT), free testosterone (FT), cortisol, and insulin responses to a high-fat test meal containing 5.44 MJ (1,300 kcal, 11% carbohydrate, 3% protein, 86% fat) were determined before (week 0) and after (week 8) an 8-week high-fat diet (64% fat) in 11 healthy men. The high-fat diet resulted in significant reductions in postabsorptive and postprandial serum triacylglycerols (55% and 50%, respectively). There were no significant changes in postabsorptive serum TT, FT, and cortisol, but insulin concentrations were significantly (P < or = .05) lower at week 8 (-28%). There was a significant reduction 1 hour after the fat-rich meal for TT (-22%) and FT (-23%), which remained significantly below baseline for 8 hours. Postprandial TT and FT responses were not significantly different after the 8-week high-fat diet. Postprandial serum cortisol concentrations were significantly reduced 1 hour after the meal. There were no significant differences before and after the high-fat diet. Insulin was significantly increased at the 0-, 1-, and 2-hour postprandial time points before and after the high-fat diet. Compared with week 0, insulin concentrations were significantly lower prior to and immediately after the fat-rich meal at week 8. These data indicate a fat-rich meal results in a prolonged reduction in TT and FT concentrations that is not altered by lowering postprandial chylomicrons. Alternative mechanisms (eg, higher uptake at the receptor level of cells) other than chylomicron-induced or insulin-induced inhibition of steroidogenesis are likely responsible for the reduction in TT and FT after a fat-rich meal.
Authors:
J S Volek; A L Gómez; D M Love; N G Avery; M J Sharman; W J Kraemer
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  50     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-07     Completed Date:  2001-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1351-5     Citation Subset:  IM    
Copyright Information:
Copyright 2001 by W.B. Saunders Company
Affiliation:
Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Chylomicrons / blood
Dietary Fats*
European Continental Ancestry Group
Fasting / physiology*
Humans
Hydrocortisone / blood
Insulin / blood
Lipids / administration & dosage*
Male
Postprandial Period / physiology*
Testosterone / blood*
Time Factors
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Chylomicrons; 0/Dietary Fats; 0/Lipids; 0/Triglycerides; 11061-68-0/Insulin; 50-23-7/Hydrocortisone; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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