Document Detail

Effects of high erucic acid rapeseed oil on fatty acid oxidation in rat liver.
MedLine Citation:
PMID:  1764215     Owner:  NLM     Status:  MEDLINE    
The effects of high erucic acid rapeseed oil (HER) on fatty acid oxidation in rat liver compared with low erucic acid rapeseed oil (LER) were studied. Weanling male SD rats were fed diets containing 20% HER or LER for 1 week or 4 weeks, or 5% HER diet for 4 weeks. The hepatic oxidation capacity of butyric acid or palmitic acid was determined by titrating the propanone produced by their oxidation. The results showed that feeding HER to rats led to an increase in the weight of liver and a decrease in the hepatic oxidation capacity of palmitic acid. Hepatic oxidation of butyric acid was not influenced by the intake of HER. The inhibitory action of HER on the oxidation of long-chain fatty acids probably resulted from the incorporation of erucic acid into mitochondrial membranes, interfering the fatty acyl-CoA transferring system on the membranes, but not from the beta-oxidation enzyme system in mitochondria being directly inhibited.
L S Zhang; Y Tan; Y L Ouyang; R S Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedical and environmental sciences : BES     Volume:  4     ISSN:  0895-3988     ISO Abbreviation:  Biomed. Environ. Sci.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-02-18     Completed Date:  1992-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8909524     Medline TA:  Biomed Environ Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  262-7     Citation Subset:  IM    
Department of Nutrition & Food Hygiene, School of Public Health, West China University of Medical Sciences, Sichuan.
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MeSH Terms
Erucic Acids / analysis*
Fatty Acids / metabolism*
Lipidoses / chemically induced
Liver / drug effects*,  metabolism
Plant Oils / chemistry,  pharmacology*
Random Allocation
Rats, Inbred Strains
Reg. No./Substance:
0/Erucic Acids; 0/Fatty Acids; 0/Plant Oils; 1072-39-5/erucic acid; 8002-13-9/rapeseed oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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