Document Detail

Effects of high doses of magnesium in drinking water and voluntary wheel running on magnesium and calcium concentrations in rats.
MedLine Citation:
PMID:  12635868     Owner:  NLM     Status:  MEDLINE    
The effect of high magnesium intake in addition to supplementation and voluntary wheel activity on magnesium and calcium homeostasis was investigated in rats. Thirty-six 5-week-old male Wistar rats were divided into four groups (n = 9). Groups 2 and 4 received five hundred ppm of elemental magnesium as MgCl2 provided in drinking water. After 1 week of acclimatization and 4 weeks of supplement and/or exercise, the animals were fasted and sacrificed. It appears that magnesium supplementation as well as exercise played some significant role in the homeostatic changes of magnesium and calcium. This could be of great significance in better understanding of mineral homeostasis particularly in sports medicine.
S C Meludu; M Nishimuta; N A Aboh; C Okonkwo; C E Dioka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnesium research : official organ of the International Society for the Development of Research on Magnesium     Volume:  15     ISSN:  0953-1424     ISO Abbreviation:  Magnes Res     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-03-14     Completed Date:  2003-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8900948     Medline TA:  Magnes Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
Lab. Fatigue Physiology, The National Institute of Health and Nutrition, Tokyo, Japan.
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MeSH Terms
Body Weight / drug effects
Calcium / blood,  metabolism*
Homeostasis / physiology
Magnesium / administration & dosage,  metabolism*,  pharmacology*
Motor Activity / drug effects*
Rats, Wistar
Weight Gain / drug effects
Reg. No./Substance:
7439-95-4/Magnesium; 7440-70-2/Calcium; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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