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Effects of high dose intravenous immunoglobulin in two severe corticosteroid insensitive asthmatic patients.
MedLine Citation:
PMID:  9246143     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preliminary observations of the clinical efficacy of intravenous immunoglobulin in two patients with severe corticosteroid insensitive asthma are reported. In both patients treatment with intravenous immunoglobulin resulted in clinical improvement and enabled a significant reduction in the dose of prednisolone. In one of the patients fibreoptic bronchoscopy with endobronchial biopsies was performed and peripheral blood was analysed by flow cytometry before and after treatment. Immunohistological analysis of the biopsy samples after treatment showed a decrease in the number of all cell types, especially CD3+ T cells, CD4+ T cells, and activated CD25+ T lymphocytes, which was associated with a reduction in peripheral blood T cell activation. Intravenous immunoglobulin may be a valid option for the treatment of corticosteroid insensitive asthma. To elucidate the role and mode of action of intravenous immunoglobulin further studies in larger groups of patients are needed.
Authors:
B Vrugt; S Wilson; E van Velzen; A Bron; J K Shute; S T Holgate; R Djukanovic; R Aalbers
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Thorax     Volume:  52     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-14     Completed Date:  1997-08-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  662-4     Citation Subset:  IM    
Affiliation:
Pathology Department, University Hospital, Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Asthma / blood,  immunology,  therapy*
B-Lymphocytes / pathology
Biological Markers / blood
Blood Proteins / analysis
Budesonide
Chronic Disease
Combined Modality Therapy
Eosinophil Granule Proteins
Female
Glucocorticoids / therapeutic use
Humans
Immunoglobulin E / blood
Immunoglobulin G / blood
Immunoglobulins, Intravenous / administration & dosage*
Inflammation Mediators / blood
Interleukin-8 / blood
Lymphocyte Count
Prednisolone / therapeutic use
Pregnenediones / therapeutic use
Ribonucleases*
T-Lymphocytes / pathology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Proteins; 0/Eosinophil Granule Proteins; 0/Glucocorticoids; 0/Immunoglobulin G; 0/Immunoglobulins, Intravenous; 0/Inflammation Mediators; 0/Interleukin-8; 0/Pregnenediones; 37341-29-0/Immunoglobulin E; 50-24-8/Prednisolone; 51333-22-3/Budesonide; EC 3.1.-/Ribonucleases
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