Document Detail

Effects of high-dose growth hormone on glucose and glycerol metabolism at rest and during exercise in endurance-trained athletes.
MedLine Citation:
PMID:  16263834     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Recombinant human-GH (r-hGH), in supraphysiological doses, is self-administered by athletes in the belief that it is performance enhancing. OBJECTIVE: The objective of this study was to determine whether r-hGH alters whole-body glucose and glycerol metabolism in endurance-trained athletes at rest and during and after exercise. DESIGN: This was a 4-wk double-blind placebo-controlled trial. SETTING: This study was conducted at St. Thomas Hospital (London, UK). PARTICIPANTS: Twelve endurance-trained male athletes were recruited and randomized to r-hGH (0.2 U/kg.d) (n = 6) or identical placebo (n = 6) for 4 wk. One (placebo group) withdrew after randomization. INTERVENTION: Intervention was conducted by randomization to r-hGH (0.2 U/kg x d) or identical placebo for 4 wk. MAIN OUTCOME MEASURES: Whole-body rates of appearance (Ra) of glucose and glycerol (an index of lipolysis) and rate of disappearance of glucose were measured using infusions of d-[6-6-2H2]glucose and 2H5-glycerol. RESULTS: Plasma levels of glycerol and free fatty acids and glycerol Ra at rest and during and after exercise increased during r-hGH treatment (P < 0.05 vs. placebo). Glucose Ra and glucose rate of disappearance were greater after exercise during r-hGH treatment (P < 0.05 vs. placebo). Resting energy expenditure and fat oxidation were greater under resting conditions during r-hGH treatment (P < 0.05 vs. placebo). CONCLUSIONS: r-hGH in endurance-trained athletes increased lipolysis and fatty acid availability at rest and during and after exercise. r-hGH increased glucose production and uptake rates after exercise. The relevance of these effects for athletic performance is not known.
M L Healy; J Gibney; C Pentecost; P Croos; D L Russell-Jones; P H Sönksen; A M Umpleby
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2005-11-01
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  91     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-10     Completed Date:  2006-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-7     Citation Subset:  AIM; IM    
Department of Diabetes and Endocrinology, Guy's, King's and St. Thomas' School of Medicine, St. Thomas Hospital, London SE1 7EH, United Kingdom.
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MeSH Terms
Blood Glucose / metabolism*
Calorimetry, Indirect
Cross-Over Studies
Dietary Carbohydrates / metabolism
Double-Blind Method
Energy Metabolism / drug effects
Exercise / physiology*
Exercise Test
Fatty Acids / metabolism
Fatty Acids, Nonesterified / blood
Glycerol / metabolism*
Growth Hormone / pharmacology*
Human Growth Hormone / blood
Lipolysis / drug effects
Physical Endurance / physiology*
Physical Fitness / physiology*
Rest / physiology*
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 12629-01-5/Human Growth Hormone; 56-81-5/Glycerol; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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