Document Detail


Effects of high PCO2 on ventilated preterm lamb lungs.
MedLine Citation:
PMID:  12595596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High PCO(2) levels attenuate reperfusion injury and ventilation-induced injury in isolated and perfused lungs. We asked whether premature lambs could tolerate 6 h of ventilation with a PCO(2) >80 mm Hg and whether the high PCO(2) modulated the ventilator-induced injury. Preterm surfactant-treated lambs were ventilated for 30 min with a high tidal volume (V(T)) to induce lung injury. The lambs then were ventilated for 5.5 h with a V(T) of 6-9 mL/kg to achieve a PCO(2) of 40-50 mm Hg in the control group. CO(2) was added to the ventilator circuit of a high PCO(2) group to maintain an average PCO(2) of 95 +/- 5 mm Hg. The high PCO(2) lambs had heart rates, blood pressures, plasma cortisol values, and oxygenation equivalent to the control lambs. The lungs of the high PCO(2) group had significantly higher gas volumes and had less lung injury by histopathology. Indicators of inflammation (white blood cells, hydrogen peroxide production, and IL-1beta and IL-8 cytokine mRNA expression in cells from the alveolar wash) qualitatively indicated less injury in the high PCO(2) group, although the differences were not significant. Preterm lambs tolerated a very high PCO(2) without physiologic compromise for 6 h. The high PCO(2) may attenuate ventilator-induced lung injury in the preterm.
Authors:
Marya Strand; Machiko Ikegami; Alan H Jobe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  53     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-21     Completed Date:  2003-08-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  468-72     Citation Subset:  IM    
Affiliation:
Division of Pulmonary Biology, Cincinnati Children's Hospital, Cincinnati, Ohio 45229-3039, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bronchopulmonary Dysplasia / etiology,  metabolism,  therapy*
Carbon Dioxide / blood*
Cytokines / genetics
Female
Gene Expression / immunology
Gestational Age
Humans
Hydrogen-Ion Concentration
Infant, Newborn
Lung / physiopathology*
Pneumonia / etiology,  metabolism,  therapy
Pregnancy
Respiration, Artificial / adverse effects*
Sheep
Grant Support
ID/Acronym/Agency:
DH-12714/DH/BHP HRSA HHS
Chemical
Reg. No./Substance:
0/Cytokines; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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